胆固醇酯转运蛋白-TaqIB基因多态性与冠心病的相关研究  

Association between cholesteryl ester transfer protein-TaqlB polymorphism and coronary heart disease

作　　者：李虎[1] 赵水平[2] 

机构地区：[1]南京大学医学院附属鼓楼医院心脏科,210008 [2]中南大学湘雅医学院附属第二医院心脏科

出　　处：《中国医师进修杂志（内科版）》2009年第12期1-5,共5页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨胆阿醇酯转运蛋白（CETP）-TaqIB基因多态性与冠心病的相关性。方法采用聚合酶链反应-限制片长多态性分析方法对238例冠心病患者（冠心病组）和203例非冠心病者（对照组）进行检测。结果所有受试者中CETP．TaqIB等位基因B1、B2的分布频率分别为59．4％（262／441）和40．6％（179／441）。冠心病组B181基因型频率高于对照组[39．9％（95／238）比29．6％（60／203）．P〈0．05]，而B182基因型频率低于对照组[44．1％（105／238）比53．7％（109／203），P〈0．05]。B1B1基因型高密度脂蛋门胆固醇（HDL-C）水平及载脂蛋白（apo）AI水平显著低于B282基因型[（1．19±0．36）mmol／L比（1．38±0．39）mmol／L，（1．17±0．33）g／L比（1．30±0．31）g/L，P〈0．05]。在57例行冠状动脉造影的冠心病患者中，B1纯合子冠状动脉狭窄程度显著高于等位基因B2携带者（P〈0．05）。多因素Logistic回归结果显示B181基因型作为独立危险因素未达到有统计学意义（P：0．147）。结论CETP-TaqIB基因多态性可影响脂蛋n水平，B181基因型与低HDl-C、低apoAI水平有密切关系.CETP-TaqIB基因型与冠状动脉狭窄程度相关，但作为冠心病的独立危险因素未能证实．Objective To determine the frequency of the cholesteryl ester transfer protein （ CETP）- TaqIB polymorphism and investigate its relationship with plasma lipid levels and coronary heart disease （CHD）. Methods Two hundred and thirty-eight patients with CHD （CHD group） and 203 age-matched controls （control group ） were selected, the CETP -TaqIB mutation was detected by restriction fragment length polymorphism of the CETP gene. Results In the total subjects, the frequency of BI and B2 alleles were 59.4%（262/441 ） and 40.6%（ 179/441 ） respectively. Compared with that in control group, the frequency of CETP genotype BIB1 was higher in CHD group [39.9%（95/238） vs 29.6%（60/203）, P 〈 0.05], and the frequency of B 1 B2 was lower in CHD group [ 44.1% （ 105/238 ） vs 53.7% （ 109/203 ）, P 〈 0.05 ]. Compared with that in the B2 homozygotes, high density lipoprotein cholesterol （HDL-C） and apolipoprntein（ apn ）A I level were significantly lower in the B I homozygotes [ （1.19 ± 0.36） mmol/L vs （1.38 ±0.39） retool/L, （ 1.17 ± 0.33 ） g/L vs （ 1.30 ± 0.31 ） g/L, P〈 0.053. The BI homozygotes was associated with higher degree of cononary stenosis than the B2 carriers （ P〈 0.05 ）. There was no significant association between CETP-TaqlB genotype and the risk of CHD （P = 0.147）. Conclusions CETP-TaqIB polymorphism affects the concentrations of lipoprateins. There are significant associations between the BI homozygotes and lower HDL-C and apo A I levels. The BI allele is not an independent risk factor for CHD.

关 键 词：冠状动脉疾病 胆同醇酯转运蛋白质类 多态性 脂蛋白类 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]