骨性关节炎的发病机制及其与Wnt/β-catenin信号通路的关系  

Pathogenesis of osteoarthritis and its relationship with the Wnt/β-catenin pathway

作　　者：王哲彦[1] 王文雅[1] 张柳[2] 

机构地区：[1]华北煤炭医学院病理教研室 [2]华北煤炭医学院附属医院骨科,河北唐山063000

出　　处：《中国矫形外科杂志》2009年第23期1800-1803,共4页Orthopedic Journal of China

基　　金：河北省科技领军人才创新基金项目(编号:06547008D-8)

摘　　要：[目的]探讨Wnt/β-catenin信号通路在骨性关节炎发病过程中的重要作用。[方法]广泛查阅近年来有关骨性关节炎发病机制的国内外文献,并进行总结和分析。[结果]骨性关节炎的病变特征为软骨破坏和骨赘形成同时伴有滑膜的病变,近期研究证实Wnt/β-catenin信号通路在骨性关节炎发病中起着至关重要的作用。[结论]骨性关节炎是在诸多危险因素联合作用下的一种进行性病变,Wnt/β-catenin信号通路在骨性关节炎发病中起着至关重要的作用。The recently published articles about the pathogenesis of osteoarthritis were reviewed. Osteoarthritis （ OA ） is characterized by cartilage degradation, osteophyte and involvement of the synovium. Mechanics, inflammatory mediators and aging collide studies in developmental, genetic and joint disease models indicate that Wnt/β -catenin signaling is critically involved in these processes. Many different factors contribute to the onset and progression of OA and Wnt/β - eatenin signaling plays a vital role in these processes.

关 键 词：骨性关节炎 软骨破坏 WNT/Β-CATENIN信号通路 

分 类 号：R684.3[医药卫生—骨科学]