阿苯达唑脂质体治疗肝、腹部细粒棘球蚴病的动物实验研究  

EXPERIMENTAL STUDY ON TREATMENT OF ECHINOCOCCOSISGRANULOSUS IN LIVER AND ABDOMEN WITHLIPOSOMEENTRAPPED ALBENDAZOLE

作　　者：邵英梅[1] 温浩[1] 

机构地区：[1]新疆医学院第一附属医院普外科

出　　处：《中国寄生虫病防治杂志》1998年第3期191-195,共5页Chinese Journal of Parasitic Disease Control

基　　金：国家"九五"攻关项目

摘　　要：应用阿苯达唑脂质体（ＬｉｐｏｓｏｍａｌＡｌｂｅｎｄａｚｏｌｅ，Ｌ－ＡＢＺ）联合西咪替丁（Ｃｉｍｅｔｉｄｉｎｅ，ＣＭＤ）治疗继发性感染细粒棘球蚴（Ｅｃｈｉｎｏｃｏｃｃｕｓｇｒａｎｕｌｏｓｕｓ，Ｅ．ｇ．），并比较单纯或联合用药的优劣。经囊减重率、药物浓度监测、病理及超微结构指标观察，结果表明：（１）阿苯达唑脂质体治疗包虫病的效果优于单纯阿苯达唑，尤其联合西米替丁效果更佳（囊减重率９５．７４％）；（２）脂质体包封阿苯达唑具有靶器官作用，可提高肝药浓度（１．５～２倍），使囊组织及囊液有较高浓度有效成分直接发挥抗包虫的作用；（３）西咪替丁可改变阿苯达唑代谢过程，提高药物浓度在小鼠体内分布。This paper reported the effect of liposomal albendazole (LABZ) on experimental Echinococcus granulosus(E.g.) and effect of coadministration with cimetidine(CMD). Experimental animals were divided into four testing groups and one control group. The major judging creteria included reduction rate of cyst weight; histopathological changes of the cyst both microscopically and electronmicroscopically concentration of ABZ and its main metabolites, ABZsulfone (ABZSN), ABZsulfoxide(ABZSX). The results indicated: 1. The liposomalABZ had greater effect than free ABZ especially coadministration with cimetidine. The reduction rate was 95.74% in LABZ/CMD group, 87.15% in LABZ group,79.08% in free ABZ/CMD group and 68.18% in free ABZ group respectively. 2. These experimental data suggested that liposome played a role in targeting liver tissue and improvement of uptake and absorption for albendazole in vivo. It may help the drugs penetrating cyst tissue and cyst fluid, maintaining high concentration and performing direct antihydatid activity. 3. Cimetidine had a profound effect on the ABZ metabolism, which appeared to be a synergistic interrelation between two drugs.

关 键 词：棘球蚴病 包虫病 阿苯达唑 西咪替丁 治疗 

分 类 号：R532.320.5[医药卫生—内科学]