塞来昔布超前镇痛在开胸手术中的应用  

Preemptive analgesia effect of celebrex in patients undergoing lobectomy

作　　者：朱幸沨[1] 郑明峰[1] 朱燕[1] 陈静瑜[1] 何毅军[1] 陈若[1] 朱乾坤[1] 叶书高[1] 刘峰[1] 陆荣国[1] 

机构地区：[1]南京医科大学附属无锡市人民医院胸外科,无锡214023

出　　处：《江苏医药》2009年第12期1455-1456,共2页Jiangsu Medical Journal

基　　金：南京医科大学科技发展基金(08NMUM088)

摘　　要：目的探讨术前给予选择性环氧化酶2抑制剂塞来昔布超前镇痛效果。方法60例全麻下开胸行肺部手术患者均分为三组。术后均采用相同配方芬太尼0.5 mg行病人自控静脉镇痛(PCIA)。A组术前3 d～术后7 d口服塞来昔布200 mg,一日2次;B组仅于术后口服塞来昔布7 d;C组仅行PCIA。记录术后8、24和36 h VAS疼痛评分。结果A组术后三个观察时点的痛觉VAS评分明显低于C组,24、36 h的疼痛视觉模拟评分(VAS)评分明显低于B组,PCIA自主给药次数少。结论术前使用塞来昔布的镇痛效果优于单纯术后用药。Objective To investigate the preemptive analgesia effect of celebrex （cyclooxygenase-2 inhibitor） in patients undergoing lobectomy. Methods Sixty patients scheduled for thoracotomy under general anesthesia were divided into three groups with 20 cases each, who were given patient-controlled intravenous analgesia with fentanyl 0.5 mg. The patients in group A received additional oral celebrex 200 mg bid for 10 days（ 3 days before and 7 days after surgery）, those in group B received the same dose of celebrex for 7 days aher surgery. Group C was not given celebrex as the control. Visual analog scores （VAS） were assessed at 6,20, and 36 h postoperatively. Results VAS scores at 24 and 36 h were lower in group A than those in group B （P〈0. 05）,which at 8, 24 and 36 h were lower in group A than those in group C （P〈0. 05）. PCA times were less in group A than those in groups of B and C （P〈0. 05）, which were less in group B than those in group C （P〈0.05）. Conclusion Preoperative analgesia with celebrex is better than postoperative administration of it.

关 键 词：环氧化酶2抑制剂 塞来昔布 超前镇痛 

分 类 号：R614[医药卫生—麻醉学]