中国女性血清瘦素浓度与年龄的关系及与其他种族女性的比较  

Concentration of serum leptin and age in Chinese women and comparison with other races

作　　者：张蓉[1] 廖二元[1] 伍贤平[1] 谢辉[1] 单鹏飞[1] 张红[1] 罗湘杭[1] 

机构地区：[1]中南大学湘雅二医院代谢内分泌研究所,长沙410011

出　　处：《中南大学学报（医学版）》2009年第11期1136-1141,共6页Journal of Central South University ：Medical Science

摘　　要：目的:调查中国长沙地区成年女性血清瘦素(leptin)浓度与年龄的关系,建立女性瘦素参考值,并分析其与其他种族的差异。方法:采用酶联免疫吸附法(ELISA)试剂盒,测定690例成年健康女性(年龄20～81岁)的血清瘦素浓度。美国非西班牙白人、非西班牙黑人和美国墨西哥女性的血清瘦素水平从文献获得。结果:血清瘦素水平随年龄而增加(r=0.224,P<0.01),采用3次回归模型拟合优度最佳。瘦素浓度与体质量(r=0.574)和体质量指数(r=0.618)呈显著正相关。体质量正常组、超体质量组和肥胖组,瘦素浓度的几何平均值分别为(8.94±1.82),(17.6±1.89)和(34.7±1.69)μg/L,3组之间呈明显梯度差异(P<0.01)。绝经前组、围绝经组和绝经后组瘦素浓度分别为(9.68±1.81),(11.7±1.89)和(11.4±2.21)μg/L,绝经前组显著低于围绝经组和绝经后组(P<0.05)。体质量正常组(n=539)血清瘦素浓度的参考值为5.30～12.6μg/L,本组女性瘦素浓度与年龄的拟合曲线显著低于美国非西班牙白人、非西班牙黑人和美国墨西哥女性。结论:该研究证实,中国成年女性血清瘦素浓度增高与年龄增长呈正相关,中国成年女性血清瘦素浓度参考值5.30～12.6μg/L,中国成年女性血清瘦素浓度与美国非西班牙白人、非西班牙黑人和美国墨西哥女性存在显著的种族差异。Objective To determine the relationship between concentration of serum leptin and age in females, and to establish the reference value and compare it with other races. Methods Serum leptin concentration of 690 adult healthy women （aged 20 -81 years ） was measured with ELISA. Results The serum leptin concentration increased with age （ r = 0. 224, P 〈 0. 001 ） , and cubic regression was the best-fitting model. Leptin concentration had significant positive correlation with weight （r = 0. 574 ） and body mass index （r = 0.618 ）. The geometric mean of leptin concentration in normal weight, overweight and obesity was （8.94±1.82）, （17.6 ±1.89）, and （34.7±1.69） μg/L, respectively, with significant difference among the 3 groups （P 〈0. 001 ）. Leptin in pre-menopause, peri-menopause and post-menopause women was （9.68 ± 1. 81 ） , （11. 7 ± 1. 89 ） , and （ 11.4 ± 2.21 ） μg/L, respectively. The reference value of serum leptin in normal weight females was 5.30 - 12.6 μg/L. The curve-fitting of leptin with age in this group was significantly lower than American non Hispanic White （NHW）, non Hispanic Black （NHB）, and American Mexican （AM） females. Conclusion This study provides reliable reference value of serum leptin in adult women and discovers ethnic difference with American NHW, NHB, and AM females.

关 键 词：血清瘦素 女性 参考值 种族差异 

分 类 号：R589.2[医药卫生—内分泌] R446.6[医药卫生—内科学]