自体骨髓间质干细胞移植治疗脑损伤的临床观察  

Clinical Observation of Autologous Bone Marrow Mesenchymal Stem Cell Transplantation for Treating Patients with Brain Injury

作　　者：李志营[1] 步星耀[1] 翟亚平[1] 程培训[1] 赵耀武[1] 李六一[1] 李太平[1] 梁庆华[1] 张永福[1] 

机构地区：[1]河南省人民医院神经外科,郑州450003

出　　处：《医学研究杂志》2009年第12期39-41,共3页Journal of Medical Research

基　　金：河南省科技攻关重点基金(0424410054);河南省杰出 人才计划(084200410011)

摘　　要：目的探讨自体骨髓间质干细胞移植治疗脑损伤的可行性及临床效果。方法回顾分析48例脑损伤患者行自体骨髓间质干细胞移植的临床资料。结果 48例脑损伤患者自体骨髓间质干细胞移植后 NIH 神经功能缺损评分(NIHSS)(11.2±6.3)分较治疗前(24.3±9.7)分显著降低(P<0.01)。其中29例患者感觉、运动和语言功能改善,5例昏迷患者干细胞移植后清醒,11例昏迷病人移植后昏迷程度变浅,3例无明显改善,全部患者均未出现明显毒性不良反应而顺利出院。结论自体骨髓间质干细胞移植治疗脑损伤安全有效,具有促进中枢神经系统组织及功能恢复的作用。Objective To explore the possibility and clinical effect of autologous bone marrow mesenchymal stem cell （MSCs） transplantation for treating patients with brain injury. Methods A retrospective analysis was conducted in 48 cases of brain injury treated with autologous bone marrow MSCs transplantation. Results As compared with before the treatment, the average of the National Institutes of Health stroke scores （NHISS）（11.2±6.3） of all the 48 patients were obviously lower after the treatment （24.3±9.7） （ P 〈 0.01）. The sensation, motion and linguistic function improved in 29 patients. 5 eataphora patients were awake. 11 cataphora patients improved after transplantation. 3 patients were ineffective. All of the 48 patients discharged smoothly, and no adverse events were noted. Conclusion The treatment for brain injury by autologous bone marrow MSCs transplantation is safe and effective, which can promote tissue and function recovery of central nerve system.

关 键 词：骨髓 干细胞 移植 脑损伤 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学] R395.1[医药卫生—基础医学]