聚对二氧环己酮改性研究进展  

The Research of Modified Poly(para-dixanone)

作　　者：白威[1] 陈栋梁[1] 李庆[1] 张志萍[1] 熊成东[1] 

机构地区：[1]中国科学院成都有机化学研究所,成都610041

出　　处：《化学进展》2009年第12期2696-2703,共8页Progress in Chemistry

基　　金：中国科学院"西部之光"人才培养计划

摘　　要：聚对二氧环己酮(PPDO),是一种脂肪族聚醚酯,以其优异的生物降解性、生物相容性、生物可吸收性以及优异的柔韧性、抗张强度、打结强度,被成功地应用于医用手术缝线制造,并在骨科固定材料、药物载体等领域有着巨大应用潜力。然而聚对二氧环己酮均聚物由于受到聚合方法及自身结构等方面的限制,未能在更为广泛的领域中得到应用。本文综述了近几年来聚对二氧环己酮改性的最新研究成果,主要从共混改性、化学改性、填充改性3方面进行了较为详细的论述。通过共混改性的方法可以明显改善聚对二氧环己酮在结晶度与体外降解速率等方面的物理、化学性能,而化学改性在改善聚对二氧环己酮的溶解性、分子量、热稳定性等方面发挥了巨大的作用,填充改性的优点在于聚对二氧环己酮与无机粒子性能上的互补,为拓展其应用范围提供了可能。Poly（para-dioxanone） （PPDO） is used as a biomaterial for tissue engineering, bone fracture fixation and controlled drug delivery due to its excellent biodegrability, bioabsorbability, biocompatibility and good flexibility. Furthermore, PPDO presents outstanding potential for general medical devices such as films, molded products, laminates, foams, non-woven materials, adhesives, and coatings. However, its polymerization method and structure, ete have hindered development of commercial applications. The recent progress in modifiration of poly （para-dixanone） is reviewed in this paper, which includes blending modification of PPDO, chemical modification of PPDO and filling modification of PPDO. Blending with other polymers is a simple and convenient way of modifying the crystalline and degradation properties of PPDO. Chemical modification is one way of improving the properties of poly（para-dixanone）, such as its solubility, molecular weight, thermal stability and so on. Filling modification of PPDO can implement each other＇ s complement of their advantage, and these novel properties will develop its wide application.

关 键 词：聚对二氧环己酮 改性 可降解高分子 

分 类 号：O631.5[理学—高分子化学] TQ316.6[理学—化学]