动物脑电-行为同步记录及分析系统  

Synchronous recording and analyzing system for animal's neuronal activity and behavior

作　　者：张韶岷[1,2] 陈卫东[1,3] 孙超[1,3] 于毅[1,2] 章怀坚[1,2] 江君[1,3] 代建华[1,3] 张恒义[2] 郑筱祥[1,2] 

机构地区：[1]浙江大学求是高等研究院,浙江杭州310027 [2]浙江大学生物医学工程学系,生物医学工程教育部重点实验室,浙江杭州310027 [3]浙江大学计算机科学与技术学院,浙江杭州310027

出　　处：《浙江大学学报（工学版）》2009年第11期2028-2033,共6页Journal of Zhejiang University：Engineering Science

基　　金：国家自然科学基金资助项目(30570433)

摘　　要：设计并构建一套动物脑电-行为同步记录及分析系统,系统主要包括动物行为实验装置、脑电信号与行为图像的同步记录子系统、脑电信号分析和处理子系统.当动物在实验装置中进行特定行为时,同步记录子系统同时记录动物的脑电信号和行为图像,通过分析和处理子系统,提取脑电信号的特征值,为大脑神经活动和行为之间的相关性研究提供实验平台.记录并分析大鼠在进行前肢的"伸-缩"运动时运动皮层的神经元集群活动.实验结果表明,大鼠的初级运动皮层中神经元分布式活动与前肢的动作模式密切相关,通过解读初级运动皮层的神经元集群电信号,可以获得大鼠前肢的运动信息,准确判断和区分前肢不同的动作模式.This work designed and built a synchronous recording and analyzing system for animal＇s neuronal activity and motor behavior, which composed of experimental apparatus for animal＇s behavior, synchronous recording subsystem, processing and analyzing subsystem. When the animals are performing specific task, the synchronous recorder captures both neuronal signals and behavior images, then the analyzing and processing subsystem extracts the feature values of the neuronal signals. This system provides an experimental platform for researching the correlation between neuronal activities and behaviors. The neuronal population activities were recorded and analyzed when a rat was performing ＂extend-flex＂ task. The observation showed that the distributed activity of the primary motor cortex is strongly related with the patterns of forelimb activities. By decoding the neuronal population activity from the primary motor cortex, the motion information of forelimb can be acquired and the action modes can be correctly distinguished and estimated.

关 键 词：神经元集群活动 运动行为 初级运动皮层 神经编码 脑机接口 

分 类 号：R318[医药卫生—生物医学工程]