颈椎温通胶囊对颈神经根炎大鼠体感诱发电位、行为学及病理学影响的研究  

Effect of Jingzhui Wentong Capsule on somesthetic evoked potential,behavior and pathology of rat with cervical radiculitis

作　　者：曾万玲[1] 隋艳华[1] 董学新[2] 张宏炼 左建平 

机构地区：[1]贵阳中医学院,贵州贵阳550002 [2]解放军44医院,贵州贵阳550009 [3]珠海星光制药有限公司,广东珠海519009

出　　处：《中成药》2009年第12期1820-1823,共4页Chinese Traditional Patent Medicine

摘　　要：目的:观察颈椎温通胶囊(桂枝、威灵仙、葛根、续断等)对由福尔马林诱发的大鼠颈神经根炎体感诱发电位(SEP)、行为及病理学的影响。方法:试验分二批进行:(1)将60只大鼠随机分为6组,空白对照组、模型组、颈复康组、颈椎温通胶囊大、中、小剂量组,按分组给药,测定造模手术后给药前及给药后14d各组大鼠SEP,同时观察动物行为变化。(2)144只大鼠分组及给药同前。于药后4、7、14及21d取颈神经根进行病理学观察。结果:测定及观察结果显示,各用药组大鼠异常的SEP明显恢复、颈神经受损症状显著改善,颈神经根炎症反应和纤维组织增生的病理变化较模型组明显减轻。结论:颈椎温通胶囊可明显减轻颈神经根炎病理变化及症状,并促进受损神经功能恢复。AIM：To observe the effect of Jingzhui Wentong （JZWT） Capsule （Ramulus Cinnamomi,Radix et Rhizoma clematidis,Radix Puerariae Lobatae,Radix Dipsaci,etc.） on somesthetic evoked potential （SEP）,behavior and pathology of rat s cervical radiculitis induced by formalin. METHODS：Experiments were carried out：（1） 60 SD rats were divided randomly into 6 groups：control,model and Jingfukang groups,the high,moderate and low dose groups of JZWT Capsule. Rats of these groups were given water,Jingfukang or JZWT Capsule respectively, and SEP was tested after operation and ld days after drugs were given to rats. At the same time, the animal behavior was observed daily. （2） 144 SD rats were divided into the same groups and given the same drugs as before. The nerve roots were taken out for pathological observation after 4,7,14, and 21 days with drug administration. RESULTS ： In each drug group, the normal SEP was obviously restored, symptoms of encroached nerve were notably lightened, inflammatory reaction and proliferation tissue of mimic cervical radiculitis were more obviously alleviated than that in the model group of rat. CONCLUSION： JZWT Capsule can reduce significantly pathology change of mimic cervical radiculitis in rats, and promote the recovery of nerve function.

关 键 词：颈椎温通胶囊 颈神经根炎 SEP 行为学 病理学 

分 类 号：R285.6[医药卫生—中药学]