去甲斑蝥素-海藻酸/聚酸酐微球的制备及表征研究  

Preparation of norcantharidin alginic acid/poly(lactide-co-glycolide) microspheres and the research of it's physico-chemical property

作　　者：李琦[1] 范忠泽[1] 王炎[1] 周利红[1] Paul Heng 

机构地区：[1]上海中医药大学附属普陀医院,上海200062 [2]新加坡国立大学药学院

出　　处：《中成药》2009年第12期1837-1841,共5页Chinese Traditional Patent Medicine

基　　金：上海市重点学科(第三期)经费资助项目(S30302);上海市自然科学基金资助项目(03ZR14083);中新(新加坡)国际合作项目(NUS-SPT200401)

摘　　要：目的:以海藻酸和聚酸酐为辅料,采用改良的乳化—化学交联法,制备新型介入栓塞剂去甲斑蝥素-海藻酸/聚酸酐微球。方法:通过正交实验结合多指标评价法优选最佳制备工艺,并考察其各项理化性质。结果:制备的去甲斑蝥素微球光滑圆整,平均粒径为(46.9±5.4)μm,以零级释药模式持续释放药物24h以上。其平均包封率、载药量分别为(78.27±2.08)%、(4.3±1.0)%。结论:制备的微球,流动性好,粒径分布集中,药物释放稳定。AIM：To use alginic acid and poly（lactide-co-glycolide） as adjuvants to prepare a new type of intervention embolism agent-norcantharidin alginic acid/poly（lactide-co-glycolide） microsphere under the help of the improved emulsive-chemical crosslinking method. METHODS：Relying on the orthogonal design in combination with the multicomponent evaluation,good preparation and physico-chemical property were selected. RESULTS：The microsphere gained had a spherical form,its mean particle size was in the range of （46.9±5.4 ） μm. The mean entrapment rate and loading level were （78.27±2.08） % and （4.3±1.0） %, respectively. CONCLUSION： The prepared microspheres which have fine fluidity, intensive size distribution and drug release is stable.

关 键 词：去甲斑蝥素 海藻酸 聚酸酐 微球 药物释放 介入 

分 类 号：R944.27[医药卫生—药剂学]