维生素E、硒对镉暴露大鼠脂质过氧化反应及环核苷酸含量的影响  

Effect of Vitamin E and Se on Cyclic Nucleotide in Cd Exposed Rats

作　　者：吴小南[1,2] 盛健[1,2] 汪家梨[1,2] 黄芳[1,2] 

机构地区：[1]福建医科大学卫生学教研室 [2]福建医科大学生物化学教研室

出　　处：《中国公共卫生学报》1998年第5期301-303,共3页

摘　　要：采用纯种Ｗｉｓｔａｒ大鼠，随机分为５组：正常对照组、镉处理组、ＶＥ＋镉联合处理组、硒＋镉联合处理组与ＶＥ＋硒＋镉联合处理组。连续观测４周。观察血清及肝匀浆脂质过氧化物（ＬＰＯ）、肝匀浆谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）、血浆环磷酸腺苷（ｃＡＭＰ）、环磷酸鸟苷（ｃＧＭＰ）、肝匀浆ｃＡＭＰ、肝组织镉（Ｃｄ）含量等指标。结果显示３个联合处理组的血ＬＰＯ、ｃＡＭＰ和ｃＧＭＰ均比镉处理组明显降低，且ＶＥ＋硒＋镉联合处理组的减低程度最明显。从肝组织ＬＰＯ、ｃＡＭＰ和Ｃｄ３个指标看，３个联合处理组均比镉处理组明显降低，且ＶＥ＋硒＋镉联合处理组的减低程度更明显。３个联合处理组的ＧＳＨ－ＰＸ均比镉处理组明显增高。表明ＶＥ和硒拮抗了镉致大鼠脂质过氧化作用。In order to investigate the effect of vitamin E(VE) and selenium (Se)on rats liver lipid peroxidation caused by cadmiun(Cd),wistars rats (devided into 5 groups equal in male and female)was used to experiment with 4 weeks observation.To measure the contents of cyclic nucleotide ,and the GSH-px activity,cadmium in liver and serum lipid peroxide(LPO)concentration were determined.The results showed that LPO,cAMP and cGMP in blood of three union treatment oups (VE+Cd group,Se+Cd group and VE+Se+Cd group)decreased remarkablely comparing with Cd treatment group,VE+Se+Cd treatment group was the most remarkablely.The LPO.cAMP and Cd in liver of three union treatment groups was also decreased remarkablely comparing with Cd treatment group,VE+Se+Cd treatment group was the most remakablely too.The GSH-px activities in liver of three union treatment groups was increased remarkablely comparing with Cd treatment group.This indicates that VE and Se have synergistic antioxidation.It was suggested that VE and Se could enhance the ability to adapt to Cd by influencing the metabolism of cyclic neucleotide. 

关 键 词：维生素E 硒 镉 脂质过氧化作用 环核苷酸 

分 类 号：R977.25[医药卫生—药品] R595.205[医药卫生—药学]