尼卡地平与非洛地平治疗老年原发性高血压的比较  

Comparison of nicardipine and felodipine in the treatment of elderly hypentensive patients

作　　者：张胜高[1] 刘爱军[1] 徐军[1] 

机构地区：[1]江苏省滨海县人民医院心内科,224500

出　　处：《临床合理用药杂志》2009年第22期3-4,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的以非洛地平作对照,观察尼卡地平的降压疗效。方法选择老年高血压病患者42例,经停用所有降压药1周后,随机分成A组(21例):口服尼卡地平每天10mg;B组(21例):口服非洛地平每天5mg,连续治疗4周,观察血压、心率、肝肾功能、不良反应等指标。结果尼卡地平与非洛地平降压作用明显(P<0.05),对偶测血压、脉压有下降作用(P<0.05),2组之间降压疗效差异无统计学意义(P>0.05);用药前后心率均差异无统计学意义(P>0.05);2组生化指标治疗前后差异无统计学意义(P>0.05),患者耐受性好,不良反应较少。结论尼卡地平是治疗老年原发性高血压的有效而安全的药物。Objective To investigate the hypotensor effect of nicardipine and compare with that of felodipine.Methods 42 cases of grades elderly hypertensive patients were divided evenly into 2 groups.After one-week′s clearout period,patients of group A（n=21）received felodipine 10mg orally qd.while patients of group B（n=21）received felodipine 5mg orally qd.During 4 week′s treatment,blood pressure,heart rate,liver and kidney functions,side effects and other data of patients were measured and recorded regularly.Results Both nicardipine and felodipine exhibited significant effects in reducing blood pressure （ P 〈 0.05 ） and pulse pressure （ P 〈 0. 05 ）. Moreover, no significant difference was found betwen nicardipine and felodipine in the reduction of blood pressure （ P〉 0.05 ）. No difference was observed in heart rate before and after treatment in both groups （P 〉 0.05 ）. No significant difference was observed in both groups in biochemical parameters before and after treatment （P 〉 0.05 ）, which indicates that patients tolerated both medicines well and there were only slight sode-effects during treatment. Conclusion Nicardipine is effective and safe in treating elderly hypertensive patents.

关 键 词：尼卡地平 非洛地平 原发性高血压 动脉血压监测 

分 类 号：R544.1[医药卫生—心血管疾病]