牛膝多糖对小鼠细胞免疫功能的影响  

The Effect of Polysaccharides in Achyranthison Cellular Immune Function in NIH Mouse

作　　者：宋义平 刘彩玉[1,2] 周刚 刘雄伯 

机构地区：[1]河南省药品检验所 [2]河南省肿瘤研究所

出　　处：《中药新药与临床药理》1998年第3期158-159,共2页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：从牛膝根中提取分子量为４．１７ＫＤ的多糖（ＡＢＰ４１７０），对其影响小鼠细胞免疫功能的性质进行了实验研究。结果显示，小鼠ｉｐ１００、２００ｍｇ／（ｋｇ·ｄ）×８ｄ，可以增强Ｈ２２腹水型肝癌小鼠的自然杀伤细胞（ＮＫ）和淋巴因子（ＩＬ＿２）激活的杀伤细胞（ＬＡＫ细胞）的杀瘤活性，并显著地提高小鼠的ＴＮＦ＿α与ＩＬ＿２的产生水平，其效果与ｉｐ猪苓多糖注射液４０ｍｇ／（ｋｇ·ｄ）×８ｄ相当。Polysaccharides in Achyranthis (ABP4170) with 4.17 KD of molecular weight was extracted from the radix Achyranthis Bidentatae ,its effect on cellular immune in NIH mice was studied .The results showed that when dose was 100mg or 200mg/(Kg.d) ip in mice for 8 d ,ABP 4170 may increase cancericidal activity of NK and LAK cells in NIH mice with ascitogenous hepatocarcinoma and may increase the synthesis of tumor necrosis factor -α and interleukin-2.The effect of ABP4170 is similar to the ip dose 40mg/(Kg.d)×8 d of the injection of polysaccharides in polyporus umbellatus. The results suggested that ABP4170 may possess the anti_carcinoma potency because of its immunity_strenghthening effect.

关 键 词：牛膝多糖 药理学 细胞免疫 药物作用 

分 类 号：R285.5[医药卫生—中药学]