N,N-二[二(3-甲氧基丙基)膦基乙基]-2-乙氧基乙胺盐酸盐的合成  

Synthesis of Hydrochloride of Bis(dimethoxypropylphosphinoethyl)-ethoxyethylamine

作　　者：楚进锋[1] 王学斌[2] 

机构地区：[1]北京化工大学化工资源有效利用国家重点实验室,北京100029 [2]北京师范大学放射性药物教育部重点实验室,化学学院,北京100875

出　　处：《高等学校化学学报》2009年第12期2415-2418,共4页Chemical Journal of Chinese Universities

基　　金：北京化工大学青年教师自然科学研究基金(批准号:QN0624)资助

摘　　要：以2-乙氧基乙胺和3-氯-1-丙醇等为起始原料,经7步反应,制备了N,N-二[二(3-甲氧基丙基)膦基乙基]-2-乙氧基乙胺(PNP5)盐酸盐,其中关键步骤是后两步.PNP5盐酸盐的结构和组成通过IR,1HNMR,13CNMR,31PNMR,MS和元素分析等方法确认.[99mTcN（PNP5）（DTC）]＋[PNP5： bis（dimethoxypropylphosphinoethyl）-ethoxyethylamine, DTC： dithiocarbamate] heterocomplexes can be viewed as resulting from the selective coupling of the metal fragment [99mTcN（PNP5）]2＋ with the bidentate dithiocarbamate π-donor ligand, and these complexes have attractive potential for myocardial perfusion imaging agents. In this article, PNP5 hydrochloride was synthesized from 2-ethoxyethylamine and 3-chloro-1-propanol through seven steps successively, in which the last two steps were the key. The structure of PNP5 hydrochloride was affirmed by IR, 1H NMR, 13C NMR, 31P NMR, MS and Elemental analysis.

关 键 词：N N-二[二(3-甲氧基丙基)膦基乙基]-2-乙氧基乙胺盐酸盐 叔膦配合物 2-乙氧基乙胺 3-氯-1-丙醇 

分 类 号：O621.3[理学—有机化学] O615.4[理学—化学]