聚L-谷氨酸担载胰岛素口服微球的制备与评价  

Poly(α,L-glutamic acid) Microspheres for Oral Insulin Delivery

作　　者：韩亚冬[1,2] 夏加亮[1,2] 何盼[1,2] 田华雨[1] 陈学思[1] 景遐斌[1] 

机构地区：[1]中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,长春130022 [2]中国科学院研究生院,北京100039

出　　处：《高等学校化学学报》2009年第12期2521-2524,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:50733003);A3国际合作重大基金(批准号:20621140369);科技部国际合作重点项目(批准号:20071314);吉林省科技发展计划国际合作项目(批准号:20060701)资助

摘　　要：以聚L-谷氨酸为载体材料,采用无水乳液法制备了口服胰岛素微球,微球直径在5～20μm,载药质量分数为5%～9%.载药微球具有良好的pH敏感释放行为,在胃模拟液中2h释放量约为5%,在肠道模拟液中2h释放90%以上.考察聚合物分子量、溶液浓度、理论投药量及混合材料对微球释放行为的影响.Insulin-loaded poly（α,L-glutamic acid） microspheres for oral delivery were prepared by anhydrous emulsion system. The microspheres had diameters of 5—20 μm, and drug loading of 5%—9%. The microspheres had good pH sensitive release behavior. In gastric simulated fluid about 5% of insulin was released from microspheres after 2 h, while in intestinal simulated fluid over 90% of insulin released. The effect of polymer molecular weight, theoretical drug loading and polymer solution concentration to the microsphere release profile were investigated.

关 键 词：聚L-谷氨酸 微球 口服胰岛素 无水乳液 pH敏感药物释放 

分 类 号：O633.221[理学—高分子化学]