运脾除湿中药对妇科腹部术后患者GAS VIP的影响  

Effects on GAS and VIP in Gynecological Patients After Operation by Herbs of Strengthening the Spleen and Eliminating Dampness

作　　者：李坤寅[1] 吴佩莼[2] 关永格[2] 陈博[2] 

机构地区：[1]广州中医药大学第一附属医院妇科,广东广州510405 [2]广州中医药大学,硕士研究生广东广州510405

出　　处：《辽宁中医杂志》2009年第12期2055-2058,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：广东省中医药局基金项目(2007026)

摘　　要：目的:观察运脾除湿中药对妇科腹部术后患者胃肠功能紊乱的防治效果及血浆胃泌素(GAS)、血管活性肠肽(VIP)影响,并探讨其作用机理。方法:将51例患者随机分为治疗组(30例)和对照组(21例),治疗组术后给予运脾除湿中药运脾饮(苍术、枳实、厚朴、藿香、丹参、黄芪等)治疗,对照组术后给予温开水,各用2天。采用放射免疫法检测两组患者手术前后GAS和VIP水平,比较两组主要临床症状(恶心、呕吐、腹胀、纳呆等)改善情况及手术前后GAS和VIP水平差异。结果:所有患者于术后第1天均出现GAS明显下降(P<0.05),VIP明显升高(P<0.05)。术后第3天,治疗组患者GAS含量较术后第1天明显升高(P<0.05),VIP含量较术后第1天明显降低(P<0.05),与对照组比较有显著性差异(P<0.05)。对照组患者术后第1天和术后第3天的GAS和VIP含量比较差异无显著性(P>0.05)。经运脾除湿中药治疗后患者恶心、呕吐、腹胀、纳呆等症状较对照组有明显改善,其积分比较有显著性差异(P<0.05),结论:腹部术后患者GAS含量降低,VIP含量升高,提示GAS、VIP可能参与了术后患者胃肠功能紊乱的发病机制;运脾除湿中药能促进术后胃肠功能的恢复,明显降低妇科腹部术后患者胃肠功能紊乱症状发生率,其作用机理可能与调控术后患者的GAS、VIP水平相关。Objective ： To research tile mechanism of therapy on the patients with gastrointestinal dysfunction after abdominal operations with herbs of strengthening the spleen and eliminating dampness, as well as effects on level of GAS and VIP. Methods ： At random ,51 patients were divided into the treated group（ n = 30 ） , who was treated with Yunpi Yin（ mainly composed of Rdlizoma Atraetylodis, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Herba Eupatorii, Radix Salviae Miltiorrhizae,Radix Astragali）, and the control group （n = 21 ） , who received Warm water. We respectively examined two-group patients＇ level of GAS and VIP before the operation ,the first day morning and the third day morning after operations by radioimmunoassay. And we also observed the patients＇ improvement of the symptoms,such as nausea and vomiting, abdominal distension and poor appetite etc. Results： All patients after abdominal operations have a low-level of GAS （ P 〈 0.05 ） and an increase of VIP （ P 〈 0. 05 ）. In the third day, compared with the first day, the level of GAS increased obviously （P 〈 0.05 ）, and the level of VIP decreased obviously （P 〈 0. 05 ） in treated group. There is an obvious difference between two groups（ P 〉 0. 05）. The symptoms of he patients,such as nausea and vomiting, abdominal distension and poor appetite etc, are obviously reduced. Its integral is more significant difference（ P 〈 0. 05）. Conclusion ：It indicates that the patients after abdominal operations have a low-level of GAS and an increase of VIP. They may be involved in gastro enteric inhibition. The herbs of strengthening the spleen and eliminating dampness can obviously reducing the symptoms of he patients with gastrointestinal dysfunction after abdominal operation. The mechanism of therapy on the patients with gastrointestinal dysfunction after abdominal operations with herbs maybe relates to the change of GAS and VIP.

关 键 词：运脾除湿中药 妇科腹部术后 血浆胃泌素(GAS) 血管活性肠肽(VIP) 

分 类 号：R713[医药卫生—妇产科学]