血脂清对实验性血脂异常大鼠的降脂及抗动脉粥样硬化作用  

Effects of Xuezhiqing on Rat's Experimental Dyslipidemia and Atherosclerosis

作　　者：潘涛[1] 顾勤[1] 

机构地区：[1]南京中医药大学,江苏南京2100046

出　　处：《辽宁中医杂志》2009年第12期2183-2185,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：江苏省教育厅自然科学基金项目(05KJB360096)

摘　　要：目的:探讨血脂清对血脂异常大鼠的调脂及抗动脉硬化作用机制。方法:将SD大鼠随机分为正常组、实验对照组、血脂清治疗组、瑞舒伐他汀治疗组,应用维生素D3及高脂饲料造模,比较各组治疗前后血脂水平及动脉粥样硬化斑块病变程度。结果:①血脂清可以显著降低实验性血脂异常大鼠的血脂水平,低剂量即显示其治疗作用;②血脂清与瑞舒伐他汀的降脂作用无组间差异(P<0.05);③血脂清、瑞舒伐他汀均可有效防治血脂异常大鼠动脉粥样硬化病变的形成。结论:血脂清可以有效降低血脂水平及动脉粥样硬化病变程度,证实中医"清热化湿、涤痰消瘀"法可以通过改善血脂异常,达到防治动脉硬化的治疗作用。Objective：To explore the regulating lipid and anti - atheroselerosis effects of Xuezhiqing on rats with dyslipidemia. Methods：SD rats were randomly divided into normal group,control group,Xuezhiqing treating group, Rosuvastatin treating group, and the experimental models of dyslipidemia and atheroslerosis were established by injection of vitamin D3 with loading high fat diet. The levels of lipid and degrees of atheroselerosis pre and after treatment were compared. Results ： Xuezhiqing could markedly decrease the levels of total cholesterol（TC） and low density lipid - cholesterol（ LDL - C）. On TC and LDL - C lowering effects, no difference was found between Xuezhiqing treating group and Rosuvastatin treating group, and also between low dose Xuzhiqing and high dose Xuezhiqing. All of the three drugs could effectively prevent formation of atherosclerosis on rats with dyslipidemia. ConcIusion：Xuezhiqing could effectivly lower the levels of TC and LDL -C and could decrease the degrees of atheroslerosis. The therapeutic ways of＂ removing heat, dissolving dampness, cleansing phlegm and ameliorating blood stasis＂ by traditional Chinese medicine could prevent and treat atherosclerosis through improving dyslipidemia.

关 键 词：血脂清 血脂异常 动脉粥样硬化 瑞舒伐他汀 

分 类 号：R972.6[医药卫生—药品]