肾传入神经在2K1C肾血管性高血压发病中的作用  

The Role of Afferent Renal Nerve in Pathogenesis of 2K1C Renovascular Hypertension

作　　者：魏顺光[1] 柴象枢[1] 

机构地区：[1]山东省医学科学院基础所生理研究室

出　　处：《高血压杂志》1998年第3期225-228,共4页Chinese Journal of Hypertension

基　　金：山东省自然科学基金

摘　　要：目的研究肾传入神经（ＡＲＮ）及其中枢投射通路在二肾一夹型（２Ｋ１Ｃ）肾血管性高血压发病中的作用。方法立２Ｋ１Ｃ肾血管性高血压大鼠模型，应用脊髓背根切除术及电损毁下丘脑室旁核（ＰＶＮ）的方法以阻断肾传入神经通路，用尾套法测尾动脉收缩压。结果脊髓背根切除以及下丘脑室旁核损毁可导致２Ｋ１Ｃ大鼠收缩压明显降低，但对假２Ｋ１Ｃ动物并无明显影响。Aim To study the role of afferent renal nerve(ARN) pathway in two kidney, one clip(2K1C) renovascular hypertension. Methods The 2K1C renovascular hypertensive rat model was established in this experiment.\ The ARN pathway was blocked by the dorsal rhizotomy and electrical lesion of paraventricular nucleus of the hypothalamus(PVN).\ Systolic blood pressure of the rat was measured by tail culf method. Results Dorsal rhizotomy and destruction of PVN induced decrease of the systolic blood pressure of 2K1C rats obviously.\ No apparent hypotensive effect of dorsal rhizotomy and destruction of PVN was found on the sham 2K1C control group. Conclusion ARN plays an important role in the pathogenesis of 2K1C renovascular hypertension.

关 键 词：肾传入神经 2K1C 病理 肾血管性高血压 

分 类 号：R544.14[医药卫生—心血管疾病]