怀地黄的降压镇静抗炎作用及有效部分分析  

Effection of HuaiQing radix rehmanniae on hypotensive and sedative and Anti-inflammatory actions and analysis of it's effective part

作　　者：刘鹤香[1] 曹中亮[1] 常东明[1] 吴尚魁[1] 

机构地区：[1]新乡医学院学报编辑部

出　　处：《新乡医学院学报》1998年第3期218-221,共4页Journal of Xinxiang Medical University

摘　　要：目的探讨怀地黄降压、镇静、抗炎作用的有效部分。方法用怀地黄的乙醚、乙醇、水提取物分别进行动物实验，以观察其药理作用，将水提取物分离得到中性、酸性、碱性提取物，分析其有效部分。结果怀地黄的水提取物有显著降压、镇静、抗炎作用（Ｐ＜０．０１），而乙醚、乙醇提取物无这种作用。怀地黄水提取物的酸性部分有上述药理作用（Ｐ＜０．０５），而中性、碱性部分作用不显著。水提取物酸性部分主要含甙类、生物碱类及磷酸等成分。结论怀地黄的降压、镇静、抗炎作用的有效成分存在于水提取物中。Objective To reseach the hypotensive and sedative and anti-inflammatory actions of HuaiQing radix rehmanniae.Methods The animal expriments had been carred out by different extractes from of HuaiQing of radix rehmanniae with extracting methods of other,alcohol and water to observe theirs pharmacologic actions.The aqueous extract had been disseiated from neuter,acid and alkaline parts to analysis theirs effective part.Results The aqueous extract of HuaiQing radix rehmanniae showed markedly the wypotensive,sedative and anti-inflammatory actions (P<0.01),but the ethereal and alcoholic extracts had not these actions.The acid part of the aqueous extract had the actions ([WT5”BX〗P<0.05),asindicated above the neuter and alkaline partr had not obvionsly([WT5”BX〗P<0.05).The acid part of the aqueous extract in clude mainly glycocides,alkaloids and phos phoric acid et al.Conclusion The effective composition of HuaiQing radix rehmanniae in hy potensive,sedative and anti-inflammatory actions coexist in the acid part of the aqueous extract.

关 键 词：怀地黄 降压作用 镇静作用 抗炎作用 药理 

分 类 号：R282.710.5[医药卫生—中药学]