硫酸头孢噻利与奥硝唑注射液的配伍稳定性研究  

Study on the compatible stability of cefoselis sulfate for injection combined with ornidazole and sodium chloride injection

作　　者：何伟珍[1,2] 田伟强[1,2] 金成淼[1,2] 

机构地区：[1]浙江省丽水市中心医院 [2]温州医学院附属第五临床医学院,丽水323000

出　　处：《海峡药学》2009年第11期14-17,共4页Strait Pharmaceutical Journal

摘　　要：目的考察硫酸头孢噻利与奥硝唑氯化钠注射液配伍的稳定性。方法采用系数倍率紫外分光光度法,在261nm和319nm处不经分离直接测定配伍液中硫酸头孢噻利和奥硝唑的含量,并观察不同时间的pH值、外观。结果在室温条件下8小时内配伍液澄明,溶液颜色有较大的变化,但其pH值和含量均未发生明显的变化。结论硫酸头孢噻利与奥硝唑氯化钠注射液不能配伍使用。OBJECTIVE To study the stability of compatibility of cefoselis sulfate combined with Ornidazole and sodium chloride injection. METHODS The concentrations of cefoselis sulfate with Ornidazole in the mixed solution were directly determined at 261nm and 319nm by K-ratio spectrophotometry without separtation; the pH value and the appearance of the mixed solution were also detected at different time, RESULTS Storing for 8 hours under room temperature, the combined solution looked clear, no significant change was noted regarding the content of cefoselis sulfate and Ornidazole, but the color of the mixed solution had a slight change. There were no evident changes in pH. CONCLUSION Cefoselis sulfate and Ornidazole and sodium chloride injection can＇ t be administered compatibly.

关 键 词：硫酸头孢噻利 奥硝唑 配伍 稳定性 紫外分光光度法 

分 类 号：R942[医药卫生—药剂学]