高斯-牛顿法拟合一室模型药物血管外给药的药动学参数的电子表格程序  

Pharmacokinetical Parameters Fitting by Gauss-Newton method on Excel Software for Extravenous Administration of one-compartment model drug

作　　者：苏银法[1] 杜乐燕[2] 

机构地区：[1]浙江省温州市第二人民医院药剂科,温州325000 [2]浙江省温州医学院附属第一医院,温州325000

出　　处：《海峡药学》2009年第11期216-218,共3页Strait Pharmaceutical Journal

摘　　要：目的建立一种简便的一室模型药物血管外给药的药动学参数求解方法。方法采用残数法获得药动学参数初值,根据最小二乘方原理设计获取一室模型药物血管外给药的药动学参数(A,k,Bandka)的Excel表格程序。结果实例显示该Excel表格程序的拟合效果与DAS2.1.1药动学软件一致。结论利用Excel表格求算药动学参数是一种有效而简便的方法。OBJECTIVE To establish a convenius method to be used for obtaining pharmacokinetical parameters of extravenous administration of one-compartment model drug. METHODS Gauss-Newton Method on Microsoft Excel software was used to obtain four pharmacokinetical parameters （A, k, B and ka） of extravenous administration of one-compartment model drug. RESULTS Through an example, the powerful function with Excel to find out the optimum solution of these parameters was shown. CONCLUSION The Microsoft Excel spreadsheet is an effective method solving four-variable pharmacokinetic parameters.

关 键 词：药动学 EXCEL 高斯-牛顿法 血管外给药 参数 

分 类 号：R97[医药卫生—药品]