自发性高血压大鼠的微血管改变及其与血管内皮细胞损伤的关系  

Relationship between Microvascular Changes and Vascular Endothelial Cells Injury in Spontaneous Hypertensive Rats

作　　者：吴强[1] 曾祖荫[2] 

机构地区：[1]贵州省人民医院心内科,550002 [2]中国人民解放军44医院,550009

出　　处：《中国微循环》1998年第3期154-156,共3页Journal of Chinese Microcirculation

摘　　要：目的：探讨自发性高血压大鼠（SHR）的微血管改变与血管内皮细胞（VEC）损伤的关系。方法：以10只成年Wistar－Kyoto大鼠（WKY）为正常对照组（WKY组）。观察、计数10只成年SHR的肠壁微动脉管径和分支数，同时测定血浆亚硝酸根（NO2－）和内皮素（ET）并与WKY组对照。结果：SHR组的肠壁各级微动脉管径较WKY组变细（P＜0．01～0．001）、各级微动脉总条数较WKY组减少（P＜0．001～0．0001）；SHR组的血浆NO2-水平和K值［10g（NO2－／ET）」较WKY组低（P＜0．05～0．001），而ET较WKY组高（P＜0．05）。血压和K值分别与肠壁微动脉管径和条数呈负相关和正相关（P＜0．005～0．001）。结论：高血压的微血管结构异常与VEC损伤有密切的关系。Aim: To study the relationship between microvascular changes and vascular endothelial cells injury in spontaneous hypertensive rats(SHR).Mcthods: The diameter of the small arterioles and their out-growth number in fleum wall,the plasma nitrite (NO2- )and the plasma endothelin(ET) were studied in SHR group and Wistar-Kyoto rats group (WKY group). Results: The diameter and outgrowth number,the NO2-level and K valueLlog (NO2-/ET)] significantly reduced and the ET level rnarkedly increased in SHR group.K and the blood pressure were relative to the diameter and outgrowth number of the small arterioles. Conclu-sion: Our study suggests that the microvascular changes are closely related to vascular endothelial cells injury in SHR.

关 键 词：微血管 内皮细胞 自发性 高血压 大鼠 

分 类 号：R544.102[医药卫生—心血管疾病]