类风湿关节炎患者血清人软骨糖蛋白-39的检测和意义  

Detection and significance of serum Human cartilage glycoprotein-39 in patients with rheumatoid arthritis

作　　者：李广科[1] 李宝全[1] 巩路[1] 

机构地区：[1]天津医科大学总医院感染免疫科,天津300052

出　　处：《天津医科大学学报》2009年第4期603-605,共3页Journal of Tianjin Medical University

摘　　要：目的:探讨血清人软骨糖蛋白-39(HCgp-39)在类风湿关节炎(RA)患者中的诊断意义。方法:对40例RA患者,15例系统性红斑狼疮(SLE)患者及20例健康人,应用夹心酶联免疫吸附法(sandwich-ELISA)检测血清HCgp-39水平。同时测定RA患者类风湿因子(RF)、红细胞沉降率(ESR)和C反应蛋白(CRP)的浓度。并记录RA患者的压痛关节数、肿胀关节数、晨僵时间、双手X线、疾病活动指数28(DAS28)。分析它们与HCgp-39的相关性。结果:RA患者组血清HCgp-39的浓度为(31.95±18.54)ng/ml,高于正常对照组(18.93±13.49)ng/ml(P<0.01)和SLE组﹙20.75±11.26﹚ng/m﹙lP<0.05﹚。而后两组之间差异无统计学意义﹙P﹥0.05﹚。25例RA活动期患者血清HCgp-39的水平为(37.92±19.58)ng/ml,15例非活动期患者为(22.00±11.41)ng/ml,组间比较差异有统计学意义﹙P<0.01﹚。HCgp-39水平与RA患者的压痛关节数、肿胀关节数、ESR、CRP、RF、晨僵时间、DAS28呈正相关(P<0.05),与年龄、性别、病程、X线分期无明显关系﹙P﹥0.05﹚。结论:RA患者血清中HCgp-39水平异常增高,提示血清HCgp-39可以作为反映RA病情活动性及诊断的指标之一。Objective： To explore the diagnostic value of serum HC gp-39 in patients with rheumatoid arthritis （RA） o Methods： The serum levels of HC gp-39 were measured with sandwich-ELISA in 40 patients with rheumatoid arthritis （RA）,15 patients with systemic lupus erythematosus （SLE） and 20 normal controls. The serum levels of erythrocyte sedimentation rate （ESR）, rheumatoid factor （RF） and C-reactive protein （CRP） were examined. The number of painfull joints, the number of swollen joints, hands X-ray and disease activity score 28 were recored. The correlation among them and HC gp-39 were compared. Results： Serum HC gp-39 levels of RA patients were （31.95 ＋18.54）ng/ml, higher than that of normal controls （ 18.93＋ 13.49）ng/ml （P〈0.01 ） and patients with SLE （20.75＋ 11.26）ng/ml（P〈0.05 ）.There was no difference inthe concentration of HC gp-39 between the normal contral group and the SLE group （P 〉 0.05）. Serum levels of HC gp-39 were higher in 25 active patients （37.92＋19.58）ng/ml than that in 15 inactive patients （22.00＋11.41 ）ng/ml （P〈0.01）. HC gp-39 levels were positively correlated with the number of the painfull joints,the number of swollen joints, RF ,CRP, ESR, morning stiffness and DAS28 （P 〈 0.05）; but were not correlated with age, gender, disease course, and X-ray stage （P 〉 0.05）. Conclusion： The present date suggests that the levels of HC gp-39 are high in patients with RA. High serum level of HC gp-39 indicates high disease activity. We can use HC gp-39 as a laboratory marker of RA.

关 键 词：关节炎 类风湿 人软骨糖蛋白-39 疾病活动指数28 

分 类 号：R593.22[医药卫生—内科学]