鼻粘膜给药用明胶微球的制备  

Preparation of Gelatin Microspheres as Intranasal Administration

作　　者：唐磊[1] 王高磊[1] 田忠贞[1] 李贺[1,2] 

机构地区：[1]济南大学化学化工学院,山东济南250022 [2]济南大学医学与生命科学学院,山东济南250022

出　　处：《济南大学学报（自然科学版）》2010年第1期75-78,共4页Journal of University of Jinan(Science and Technology)

基　　金：山东省教育厅科技计划(J08LC54);山东省重点学科基金(XTD0705)

摘　　要：以明胶为原料,葡聚糖为交联剂,采用乳化化学交联固化法制备鼻粘膜给药用明胶微球。结果表明:在明胶质量浓度为0.15 g/mL,乳化剂Span 80质量浓度为0.02 g/mL,搅拌速度=800 r/min,V(液体石蜡)∶V(水)=15∶1的最优反应条件下,制备的未交联明胶微球平均粒径=47±7.6μm,葡聚糖交联明胶微球的平均粒径=38±4.2μm。Gelatin microspheres as intranasal administration were prepared by the emulsification erosslinking method, using dextran as cross]inking agent. The optimal preparation condition was obtained ： the concentrations of gelatin and emulsifying agent span 80 are respectively 15% and 2% , the stirring speed is 800 r/min, and the volume ratio of liquid paraffin to water is 15： 1. The result shows that, under the optimal conditions, the average diameter of blank gelatin microspheres is 47 ±7.6 μm, while the average diameter of dextran cross-linked gelatin microspheres is 38± 4.2 μm.

关 键 词：鼻粘膜给药 明胶 徽球 

分 类 号：TQ469[化学工程—制药化工]