S-腺苷-L-蛋氨酸治疗全肠外营养所致胆汁淤积的临床研究  

Treatment of total parenteral nutrition induced cholestasis with S adenosyl L methionine

作　　者：王少华[1] 李宁[1] 任建安[1] 朱维铭[1] 刘放南[1] 黎介寿[1] 

机构地区：[1]南京军区南京总医院解放军普通外科研究所

出　　处：《肠外与肠内营养》1998年第4期195-198,共4页Parenteral & Enteral Nutrition

摘　　要：目的：观察Ｓ┐腺苷┐Ｌ┐蛋氨酸（思美泰）治疗不中断肠外营养情况下ＴＰＮ所致胆汁淤积的疗效。方法：对８例应用ＴＰＮ＞４周、发生胆汁淤积的病人，给予ＴＰＮ支持同时应用思美泰５００ｍｇ２／ｄ，静滴，连续应用４周。结果：治疗后血浆总胆红素、γ┐谷氨酰转肽酶、碱性磷酸酶、谷丙转氨酶、谷草转氨酶明显降低（Ｐ＜０．０５）。肝脏穿刺活检示肝细胞内胆汁淤积及门管区炎症减轻，胆小管内胆栓溶解。结论：静脉给予Ｓ┐腺苷┐Ｌ┐蛋氨酸具有明显的治疗ＴＰＮ所致胆汁淤积的作用。Objectives:To observe the effects of S adenosyl L methionine on cholestasis induced by parenteral nutrition. Methods:When 8 patients had been diagnosed with cholestasis,their total parenteral nutrition had been used for more than 4 weeks.Each patient was given S adenosyl L methionine,500 mg,2 times perday,by intravenous route continously for 4 weeks. Results:Plasma concentrations of total bilirubin,γ GT,AKP,GPT and GOT were obviously reduced after the use of the drug( P <0.05).Percutanous transhepatic biopsy showed that intraceller cholestasis and inflammetion around portal areas decreased,cholochrome embolus in bile ductules had dissolved. Conclusions:Given S adenosyl L methionine by intravenous route has an obvious role in treating cholestasis from total parenteral nutrition.

关 键 词：全肠外营养 腺苷蛋氨酸 胆汁淤积 

分 类 号：R459.3[医药卫生—治疗学]