解毒口服液对大鼠实验性肝损伤内毒素血症的防护作用  

The Protective Effect of Jiedu Koufuyie on Experimental Endotoxemia in Rat

作　　者：魏嵋[1] 刘鹏[1] 张光海[1] 陈宣石 陈正芳[1] 

机构地区：[1]四川沪州医学院,沪州646000

出　　处：《中西医结合肝病杂志》1998年第3期156-158,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨中医药对肝损伤大鼠内毒素血症的防治作用。方法:应用硫代乙酰胺灌胃建立暴发性肝衰竭大鼠模型,观察解毒口服液对实验性肝损伤大鼠血浆内毒素、肝功能及肝组织病理学指标的影响。结果:解毒口服液组在降低血浆内毒素、缩短凝血酶原时间、改善肝脏病理损伤程度方面,与损伤组比较均有非常显著的差异(P<0.01);解毒护肝口服液组次之(P<0.05)。在改善肝功酶系指标方面,解毒口服液与损伤组比较亦有显著差异(P<0.05),略差于解毒护肝口服液组。结论:解毒口服液有较好改善肝脏功能、防治内毒素血症的功效。Aim:To study the effect of Chinese Medicine on preventing endotoxemia induced by TAT in rats. Method: The rats attacked with TAT were used as endotoxemia model. Amount of endotoxia, hepatic function and hepatic tissue pathology indexes were obserued. Result: In comparison with group of injury, the results show that there is a very significant different (P<0. 01) in group of Jiedu Koufuyie, and there is a significant different (P<0. 05) in group of Jiedu Hugan Koufuyie in decreasing endotoxia, shorten PT and reducing degree of hepatic injury. In improving heptic enzymes,comparising with group of injury, the group of Jiedu Koufuyie has a significant different too (P<0. 05), and the group of Jiedu Hugan Koufuyie has a very significant different (P <0. 01). Conclusion: These results indicate Jiedu Koufuyie has a good treatment in improving hep-tatic function of rats of hepatic injury and resisting endotoxemia in the rats.

关 键 词：大鼠 解毒口服液 硫代乙酰胺 内毒素血症 

分 类 号：R259.75[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]