异苯并呋喃酮-3-乙酰胺类化合物的合成及其抗惊活性构效关系的初步探讨  

Synthesis and Preliminary Inquiry into the Structure activity Relationships of Anticonvulsant Activities of Amide Derivatives of Isobenzofuran 1(3 H ) one 3 Acetic Acid

作　　者：胡高云[1,2] 向阳[1,2] 向红琳[1,2] 谭转云 陈仕才 黄浩 

机构地区：[1]湖南医学高等专科学校药学系 [2]湖南医科大学基础医学院有机化学教研室

出　　处：《中国药物化学杂志》1998年第3期169-173,共5页Chinese Journal of Medicinal Chemistry

基　　金：湖南省青年骨干教师培养基金

摘　　要：设计合成了１１个新的异苯并呋喃酮３乙酰胺类化合物，它们均未见文献报道，产物经核磁共振氢谱和元素分析确证．抗惊实验表明：当酰胺氮原子上的取代基为脂肪取代基且碳原子总数在６～１０个之间时，该类化合物才有较好的抗惊活性．new target compounds were designed and synthesized.All of them have not been reported in literature.The chemical structures of all the compounds were determined by 1H NMR and elementary analysis.Pharmacological tests showed when the sum total of carbon atoms on the nitrogen atom was between 6～8 these compounds showed anticonvulsant activity.The structure anticonvulsant activity relationships were preliminarily discussed in this paper.

关 键 词：异苯并呋喃酮 抗惊作用 抗癫痫药 合成 构效关系 

分 类 号：R971.6[医药卫生—药品]