基因重组人生长激素治疗青春期前特发性矮小儿童临床研究  

Effect of Recombinant Human Growth Hormone Therapy in Prepuberty Children with Idiopathic Short Stature

作　　者：胡女元[1] 余永芳[1] 余楚红[1] 聂翠霞[1] 张翠媛[1] 

机构地区：[1]江门市中心医院儿内科,529030

出　　处：《国际医药卫生导报》2009年第24期13-16,共4页International Medicine and Health Guidance News

摘　　要：目的观察基因重组人生长激素(rhGH)治疗青春期前特发性矮小(ISS)的疗效。方法29例青春期前特发性矮小患儿分为两组,治疗组15例,男9例,女6例,均予rhGH(0.13～0.15)U/(kg.d),临睡前皮下注射,疗程6个月至12个月;对照组14例,男7例,女7例,未给予rhGH治疗。结果治疗组治疗后生长速率(GV)为(9.27±1.6)cm/年,对照组为(4.83±2.1)cm/年,两组比较差异有非常显著意义(P<0.01),治疗后治疗组骨龄身高标准差积分(HtSDSBA)为(0.82±0.51),对照组为(1.51±0.89),两组比较差异有显著性(P<0.05),两组骨龄增长/年龄增长(△BA/△CA)比较差异无显著性(P>0.05)。结论使用rhGH治疗ISS儿童,可使生长加速,在短期内有明显的促生长作用,对骨龄的影响不大,且不会引起青春发育提前。Objective To observe the effect of recombinant human.growth hormone （ rhGH ） in treating prepuberty children with idiopathic short stature（ISS）. Methods Twenty-nine cases were divided into treating group and control group.The treating group included fifteen children with male nine,female six. They were treated with rhGH（ 0.13 ～ 0. 15 ）U/（kg·d） before night sleeping.The course of treatment was six to twelve months.The control group included fourteen children with male seven,female seven.They were not treated with rhGH.Results The growth velocity（GV） in treating group after treatment was （ 9.27±1.6 ）era/ a.And it was（ 4.83±2.1 ）cm/a in control group.There was significant difference between the two groups（P〈0. 01）.The height standard deviation score of bone age （HtSDSBA） was（ - 0.82±0.51 ） in treating group and （ - 1.51±0.89 ）in the control group.Also there was significant difference between the two groups（P〈0.05）. The ratio of △ BA （ increasing of bone age ） / △CA （ increasing of chronology age ） was not significant different in two groups（P〉 0.05）.Conclusions The rhGH can improve the GV and stimulate the growth of prepuberty children with ISS.The effect of impeling growth is obvious in short term.The rhGH brings about little effect on BA and can not cause the puberty growth in advance.

关 键 词：生长激素 特发性矮小 青春前期 

分 类 号：R725.8[医药卫生—儿科]