寒冷复合电离辐射对大鼠外周血和微核率的影响  

The effects on peripheral blood index and micronuclei rate of the coldadaption and irradiation rats

作　　者：宋聚忠[1] 谢怀江[1] 彭涛[1] 寇庆河[1] 吴建华 金焕荣[1] 

机构地区：[1]沈阳军区军事医学研究所

出　　处：《中国辐射卫生》1998年第3期131-133,共3页Chinese Journal of Radiological Health

摘　　要：为了探讨寒冷条件下机体对电离辐射的生物学效应，Ｗｉｓｔａｒ大鼠在１～５℃低温下冷适应１４天，照射４．５Ｇｙ，再移至常温饲养，为寒冷照射组，引流大鼠眼内眦动脉血作ＷＢＣ、ＬＹａ、ＬＹＰ、ＲＢＣ、ＰＬＴ、Ｈｂ等８项外周血指标和微核率测定，并以常温组、常温照射组、寒冷组作对照。结果表明，常温组、寒冷组各项指标均在正常范围。与常温照射组相比，ＷＢＣ、ＬＹａ、ＲＢＣ、ＰＬＴ、Ｈｂ下降数值小，回升速度快。照后第２８天寒冷照射组比常温照射组ＷＢＣ升高１倍左右，微核率也比较低。Wistar rats were cold-adapted under the temperatures of 1～5℃ for 14 days before irradiated 4.5 Gy by ^(60)Co γ-rays.They were the cold irradiating group.The blood drained from their angular arteriae was tested for MN rates and 8 items of WBC, LYa、LYp、RBC,etc.The groups of room temperature,room temperatureirradiation and cold-adapation were controls.The rseules showed WBC,LYa,PLT and Hb of coldadaption irradiation group declincd less and asecnded more rapidly than that of room temperatureirradiation group.The WBC counts in coldirradiation group were as double times as that in room temperature group at the twentyeighth day after irradiation,MN rate of the former was lower than that of the latter,The above prompted cold adapting rats increased resistance against irradiation and there would be the possibility to protection normal tissues by cold when patients were treated in radiotherapy.

关 键 词：冷适应 电离辐射 外周血 微核率 

分 类 号：R594.8[医药卫生—内科学]