舒芬太尼和芬太尼用于妇产科术后皮下自控镇痛的对比观察  

Comparasion of effects of sufentanil and fentanyl PCSA on post-gynecology and obstetrics surgery

作　　者：汪飞[1] 高晓枫[1] 岑雁源[1] 

机构地区：[1]广东省惠州市中心人民医院麻醉科,广东惠州516000

出　　处：《吉林医学》2009年第23期2950-2952,共3页Jilin Medical Journal

摘　　要：目的:对比舒芬太尼和芬太尼用于妇产科术后皮下自控镇痛的效果。方法:选择腰硬联合麻醉下行妇产科手术患者40例,ASAⅠ～Ⅱ级,年龄20～60岁。随机分为舒芬太尼组(S组,n=20)和芬太尼组(F组,n=20)。S组术后镇痛配方:舒芬太尼150μg+托烷司琼6mg+0.9%NaCl溶液配至100ml;F组术后镇痛配方:芬太尼1.5mg+托烷司琼6mg+0.9%NaCl溶液配至100ml,均为3d镇痛剂量。观察患者术后4h、8h、16h、24h、48h的疼痛、镇静评分,并记录有无恶心呕吐、呼吸抑制、皮肤瘙痒等不良反应。结果:VAS镇痛评分各时点S组<F组,组间比较,P<0.05;Ramsay镇静评分术后各时点S组<F组,组间比较,P<0.05;恶心、呕吐、呼吸抑制和皮肤瘙痒发生率两组无明显差别。结论:舒芬太尼和芬太尼用于妇产科术后皮下自控镇痛均可取得满意效果,但舒芬太尼效果更佳,不良反应更少。Objective To observe the effects of sufentanil and fentanyl PCSA on post - gynecology and obstetrics surgery. Method Forty patients undergoing selective gynecology and obstetrics operation, ASA Ⅰ～Ⅱ and aging 20 - 60 years old,were randomized into two groups （group S and group F） with 20 cases each. Post -operation analgesia recipe of group S： sufentanil 150μg ＋ tuowansetron 6mg ＋ 0. 9% NS,total volume was 100ml ; Post - operation analgesia recipe of group F ： fentanyl 1.5mg ＋ tuowansetron 6mg ＋ 0. 9 % NS, total volume was 100ml （3 days＇ analgesia doses）. Visual analogue scale （VAS,0- 10） and sedation scores were recorded at 4,8,12, 24 and 48 hours after PCSA, and side effects were recorded such as nausea, vomiting, respiratory depression, pruritus and so on. Results Compared with group F, VAS scores of group S at each time point in 48 hours were less and sedation scores were higher（P 〈 0.05 ）. There were no significant differences as to nausea, vomiting, respiratory depression and pruritus between the two groups. Conclusion They are both well those effects of sufentanil and fentanyl PCSA on post - gynecology produce, but sufentanil has better benefits and less adverse effects.

关 键 词：舒芬太尼 芬太尼 皮下自控镇痛 妇产科术后 

分 类 号：R614[医药卫生—麻醉学]