卵泡发育与多囊卵巢综合征相关因素的研究进展  

The relationship of follicle development and polycystic ovary syndrome

作　　者：赵玲玲[1] 张跃辉[1] 匡洪影[1] 李威[1] 吴效科[1] 侯丽辉[1] 

机构地区：[1]黑龙江中医药大学附属第一医院妇产科,哈尔滨150040

出　　处：《中国优生与遗传杂志》2009年第12期129-130,119,共3页Chinese Journal of Birth Health & Heredity

基　　金：国家自然科学基金(30572404)

摘　　要：多囊卵巢综合征(PCOS)是育龄期女性最常见的生殖内分泌紊乱疾病,可表现为高雄激素血症,高胰岛素血症,胰岛素抵抗(IR),并可引起生殖功能的障碍,该病与卵泡发育异常密切相关。人类卵泡的发育过程包括原始卵泡的募集、生长、发育、最终只有一个优势卵泡发育成熟并排卵。在这个过程中,生殖激素、内分泌、旁分泌,肽类细胞生长因子对卵泡生长发育进行规律而有序的调节,在PCOS患者中这些机制出现异常。本文就卵泡发育异常,及其与PCOS之间相关因素做一简要综述。Polycystic ovary syndrome （PCOS） is the most common reproductive endocrine disorder syndrome of reproductive women which characterized by ovarian hyperandrogenism, hyperinsulinemia from insulin resistance, and reduced fecundity. Human follicle development requires the recruitment of primordial follicles into a cohort of growing follicles from which one follicle is selected to ovulate a mature oocyte. During this developmental process, reproductive hormone, endocrine and paracrine factors on the cell growth and peptide follicle growth for law and orderly adjustment the follicle development , but in PCOS these mechanism appear abnormal. This review is focused on the follicular anomalies and the related factors in PCOS .

关 键 词：多囊卵巢综合征 卵泡发育 高雄激素血症 高胰岛素血症 

分 类 号：R711.75[医药卫生—妇产科学]