高氟对新西兰大白兔血浆TXB_2、6-Keto-PGF_(1α)及ET-1的影响  

Effects of High Fluorine on the Blood Thromboxane B_2、6-Keto-prostaglandinF_1αand Endothelin-1 of New Zealand White Rabbits

作　　者：陈兆堂[1] 蔺新英[2] 边建朝[3] 杨晓霞[3] 赵妍[1] 樊婷[2] 

机构地区：[1]山东大学齐鲁医院 [2]山东大学营养与食品卫生学研究所,山东济南250012 [3]山东大学山东省地方病防治研究所,山东济南250014

出　　处：《国外医学（医学地理分册）》2009年第4期167-170,共4页Foreign Medical Sciences：Section of Medgeography

基　　金：山东省国土资源厅资助课题(No.1212010310306)

摘　　要：目的研究高氟对新西兰兔血浆TXB_2、6-Keto-PGF_(1α)及ET-1的影响。方法20只健康雄性新西兰白兔随机分为对照组,高氟组(饮含氟离子100mg/L高氟水),高脂组(饲含胆固醇5g/kg,蛋黄粉70g/kg的高脂饲料),加脂加氟组(饮含氟离子100mg/L高氟水,饲含胆固醇5 g/kg,蛋黄粉70 g/kg的高脂饲料),于实验前、实验3、6个月取血测血氟含量;6个月后检测血浆TXB_2、6-Keto-PGF_(1α)及ET-1的含量。结果新西兰白兔饮用高氟水6个月血清氟升高;血浆6-酮-前列腺素F_(1α)(6-Keto-PGF_(α))含量降低、血栓素B_2(TXB_2)含量、内皮素-1(ET-1)含量升高(P<0.05),析因方差分析表明高氟与高脂存在交互作用(P<0.05)。结论氟能使新西兰白兔血浆6-Keto-PGF_(1α)含量降低,血浆TXB_2和ET-1含量升高,从而促进动脉粥样硬化的发生和发展。高脂对高氟饲料诱发新西兰兔形成的动脉粥样硬化有协同作用。Objective To study the effects of overdose fluorine on Thromboxane B2- 6-Keto-prostaglandinF1α and Endothelin-1 in New Zealand rabbits . Methods Twenty male rabbits were randomly divided into 4 groups： normal group, high fluorine group（the fluorine concentration is 100 mg/L water）, high-lipid group fed with high-lipid forage , high-fluorine and high-lipid group fed with high-fluorine water（the fluorine concentration is 100 mg/L） and high-lipid forage（0.5% and 7% egg yolk powder were added into the basic forage） . After six months, we assayed the level of TXBz .6- Keto-PGF1α and ET-1 in the serum. Results High fluorine diet could decrease the capacity of 6-Keto-PGF1α in the New Zealand rabbit ＇ s serum significantly, and increase the level of TXB2 and ET- 1 in serum（P〈0.05 or P〈0.01 ） ; The results of factorial design ANOVA indicated that there＇s significant synergistic action of 6-keto-PGF1α between high-fluorine and high-lipid（P〈0.05）. Conclusion Fluorosis could decrease the level of 6-Keto-PGF1α and increase the level of TXB2 and ET-1 in the serum, then there＇s significant synergistic action between groups of high-fluorine and high-lipid.

关 键 词：氟 动脉粥样硬化 前列环素 血栓素 

分 类 号：R994.6[医药卫生—毒理学]