吡那地尔对锰中毒大鼠脑内谷氨酸代谢相关酶的影响  

EFFECT OF PINACIDIL ON GLUTAMATE METABOLISM ENZYME IN RAT'S BRAIN INDUCED BY MANGANESE POISONING

作　　者：邓宇[1] 徐兆发[1] 田雅文[1] 徐斌[1] 

机构地区：[1]中国医科大学公共卫生学院环境卫生学教研室,沈阳110001

出　　处：《现代预防医学》2009年第24期4650-4651,共2页Modern Preventive Medicine

基　　金：国家自然科学基金资助项目(30771834);辽宁省教育厅科学研究基金资助项目(2004C025)

摘　　要：[目的]研究吡那地尔对锰中毒大鼠脑内谷氨酸代谢相关酶的影响。[方法]建立锰中毒及干预模型后,比较对照组、染毒组和干预组中脑GS、PAG、Na+-K+-ATP酶和Ca2+-ATP酶活力变化,用SPSS13.0软件进行数据分析。[结果]与对照组相比,染毒组内GS、Na+-K+-ATP酶和Ca2+-ATP酶活力明显降低(均P﹤0.01);PAG活力明显升高(P﹤0.01)。与染毒组比较,吡那地尔预处理组中GS和Na+-K+-ATP酶的活力明显升高(P﹤0.05,P﹤0.01);而PAG和Ca2+-ATP酶活力未见明显改变。[结论]吡那地尔对锰中毒造成的大鼠脑谷氨酸代谢酶活力改变有一定的保护作用。[Objective] To study the effect of pinaeidil on glutamate metabolism enzyme in rat＇s brain induced by manganese poisoning. [Methods] Intervention and manganismus models were established to compare the GS, PAG, Na^＋-K^＋-AT- Pase and Ca^2＋-ATPase in control, the manganese poisoning, the intervention groups. Data were analyzed by SPSS 13.0 software, [Results] Compared with the control group, the activities of GS, Na^＋-K^＋-ATPase and Ca^2＋-ATPase significantly decreased （P 〈 0.01; P 〈 0.01; P 〈 0.01）, and the activity of PAG significandy increased （P 〈 0.01） in the manganese poisoning group. Compared with the manganese poisoning group, the activity of GS and Na^＋-K^＋-ATPase significantly increased in the intervention group （P 〈 0.05; P 〈 0.01） . And the activities of PAG and Ca^2＋-ATPase did not significantly changed. [Conclusion] Pinacidil has a certain protective effect on the glutamate metabolism enzyme in rats by manganese pmsoning.

关 键 词：锰中毒 吡那地尔 谷氨酸 

分 类 号：R595.2[医药卫生—内科学]