两种梅毒检测方法对比  

Comparison of the Different Methods Examing Treponema

作　　者：于晓明[1] 胡雪峰[1] 迟丽娜[1] 

机构地区：[1]中航工业哈尔滨二四二医院,黑龙江哈尔滨150066

出　　处：《航空航天医药》2009年第12期29-30,共2页Aerospace Medicine

摘　　要：目的：比较甲苯胺红不加热血清试验（TRUST）、螺旋体明胶颗粒凝集试验（TPPA）两种梅毒血清学试验的检测结果。方法：将2008-2009年性病门诊138例确诊梅毒患者血清同时用甲苯胺红不加热血清试验TRUST试验、螺旋体明胶颗粒凝集试验TPPA试验检测,比较两种梅毒检测实验方法的灵敏度和特异性。结果：138份血清中,98份血清TRUST阳性,17份经抗梅毒治疗血清TRUST阴性,TPPA试验132份血清为阳性。结论：TRUST试验可作为梅毒的人群筛查、疗效、复发或再感染的检测指标,TPPA试验是检测梅毒螺旋体抗体的特异性方法,主要作为梅毒的确证试验。两种不同方法同时进行梅毒检测,将减少漏诊、误诊率,为梅毒的确诊提供参考依据,并且在判定梅毒的发展、痊愈及药物疗效方面都具有十分重要的意义。Objective：to select the best screening method suiting for blood donors by assessing the validity of TRUST and TPPA.Methods：TRUST was used to screen patients with syphilis from blood donors,and TPPA was used to confirmed positive results detected by TRUST.Results：the sensitivity,false positive rate and false negative rate of TRUST were 39.02%,3.03%,and 60.98% respectively.The sensitivity,false positive rate and false negative rate of ELISA were 98.73%,20.59% and 1.22%.Conclusions：The combination of TRUST and ELISA is the first choice to screen patients with syphilis from blood donors. Moreover this screening contributes to blood safety.

关 键 词：梅毒 甲苯胺红不加热血清试验(TRUST) 螺旋体明胶颗粒凝集试验(TPPA) 

分 类 号：R446.11[医药卫生—诊断学]