融斑通脉颗粒对血淤模型大鼠体外血栓形成及血液黏度的影响  

Effect of Rongban Tongmai Granules on thrombosis and blood viscosity of in vitro rat model of stasis

作　　者：袁志坚[1] 何文涓 张兰芳[1] 邓锐 

机构地区：[1]无锡卫生高等职业技术学校,江苏无锡214111 [2]无锡山禾药业股份有限公司,江苏无锡214062

出　　处：《中国生化药物杂志》2009年第6期412-414,418,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的观察融斑通脉颗粒对血瘀模型大鼠体外血栓形成及血液黏度的影响,研究该药的活血作用。方法通过皮下注射盐酸肾上腺素,再以冰水刺激法复制大鼠＂血瘀＂模型,观察融斑通脉颗粒对模型大鼠体外血栓形成及血液黏度的影响。结果连续7 d灌胃给药,融斑通脉颗粒明显缩短血瘀模型大鼠的体外血栓长度（P〈0.05-0.01,明显降低血栓湿重和干重（P〈0.05）,明显降低切变率100,30,5 S^-1下的全血黏度（P〈0.05-0.01）,对切变率200 S^-1下的全血黏度有降低趋势。结论融斑通脉颗粒具有抑制血栓形成、降低血液黏度的作用。Purpose To observe the effect of Rongban Tongmai Granules on thrombosis and blood viscosity of in vitro rat model of blood stasis, and to study the activating blood circulation effect of the drug. Methods To observe the effect of the Rongban Tongmai Granules on thrombosis and blood viscosity of in vitro rat model of stasis, subcutaneous inject rat with epinephrine hydroehloride, and then copy ＂blood stasis＂ model by ice water stimulation in rats. Results According to a continuous 7 days＇ intragastric administration of Rongban Tongmai Granules, thrombus length of blood stasis model rats in vitro reduced significantly （ P 〈 0.05-0.01） ,wet and dry weight of thrombus reduced significantly （P 〈 0.05）, the shear rate of the whole blood viscosity under 100 S^-1 30 S^- 1, 5 S^-1 decreased significantly as well （ P 〈 0.05-0.01 ） , and the shear rate of whole blood viscosity had decreasing tendency under 200 S^-1. Conclusion Rongban Tongmai Granules can inhibit thrombosis and lower blood viscosity.

关 键 词：融斑通脉颗粒 血栓 血液黏度 

分 类 号：R285[医药卫生—中药学]