半枝莲的化学成分  

Chemical Constituents of Scutellaria barbata D.Don

作　　者：李宁[1] 肖海涛[1] 孟大利[1] 王金辉[1] 李铣[1] 

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《中国现代中药》2009年第12期16-17,20,共3页Modern Chinese Medicine

摘　　要：目的:对黄芩属植物半枝莲Scutellaria barbata D.Don全草的抗肿瘤活性部位(三氯甲烷萃取物)的化学成分进行分离、鉴定。方法:采用反复硅胶、LH-20葡聚糖凝胶等柱色谱方法进行分离纯化,并通过理化常数测定与谱学分析鉴定其化学结构。结果:得到7个化合物,分别鉴定为木犀草素(1),柚皮素(2)、半枝莲酸(3),2,4-二羟基苯甲酸(4),香豆酸乙酯(5),β-谷甾醇(6),胡萝卜苷(7)。结论:化合物4、5为首次从半枝莲中分离得到。Objective： To study the chemical Methods： Compounds were isolated by chromatograph constituents of antitumor active part of Scutellaria barbata D. Don. y on silica gel, Sephadex LH-20 column and identified on the basis of physico-chemical constants and spectral analysis. Results： Seven compounds were obtained and their structures were identified as luteolin （ 1 ）, naringenin （2）, scutellaric acid （3）, 2,4-dihydroxybenzoic acid （4）, p-coumaric acid acetate （5）,β-sitosterol（6）, daucosterol（7）. Conclusion： Compounds 4 and 5 were isolated from S. barbata for the first time.

关 键 词：半枝莲 抗肿瘤活性部位 化学成分 

分 类 号：R284.1[医药卫生—中药学] R282.71[医药卫生—中医学]