氟伐他汀对1型糖尿病大鼠心功能损伤的保护作用  

Effect of Fluvastatin on Cardiac Function and Ventricular Remodeling in Diabetic Rats

作　　者：寇华炜[1] 赵倩[1] 刘红梅[2] 张玉玲[2] 张如意[3] 余建强[2,4] 

机构地区：[1]宁夏医科大学研究生部,银川750004 [2]宁夏医科大学基础医学院临床前基础医学综合实验室,银川750004 [3]宁夏医科大学附属医院内分泌科,银川750004 [4]宁夏医科大学基础医学院药理学系,银川750004

出　　处：《宁夏医科大学学报》2009年第6期716-719,F0002,共5页Journal of Ningxia Medical University

基　　金：宁夏回族自治区高等学校科学技术研究项目[宁教高(2007)292号]

摘　　要：目的观察氟伐他汀(Fluvastatin,Flu)对糖尿病大鼠心功能及心室重塑的影响。方法SD大鼠,腹腔注射链脲佐菌素制备糖尿病模型。观察氟伐他汀及氟伐他汀与胰岛素(Insulin,Ins)联合治疗对糖尿病大鼠体重、血糖、心功能及心室重塑的影响。结果氟伐他汀对糖尿病大鼠体重、血糖无明显影响(P>0.05),可减少糖尿病大鼠心电图异常的发生,减缓左室收缩压、左室舒张末期压、左室内压变化速率和左室内压上升达最大速率所需时间等心功能指标的恶化,以及抑制左心室肥厚和左心室指数的增加(P<0.05)。结论氟伐他汀对糖尿病大鼠心肌病变具有保护作用。Objective To observe the effects of fluvastatin on cardiac function and ventricular remodeling in diabetic rats. Methods Diabetic model was established by administration of steptozotoein intraperitoneally in SD rats to observe the effects of fluvastatin and combined insulin therapy on body weight, blood sugar, 24hours metabolism, cardiac function and ventricular remodeling of diabetic rats. Results There were no significant effects of fluvastatin on body weight, blood sugar and 24hours metabolism on diabetic rats （ P 〉 0.05）, however, fluvastatin improved the parameters of ECG, cardiac function and ventricular remodeling in diabetic rats（ P 〈 0.05）. Conclusion Fluvastatin has a protective effect on myocardiopathy in diabetic rats.

关 键 词：氟伐他汀 糖尿病心肌病变 心功能 心室重塑 大鼠 

分 类 号：R587.1[医药卫生—内分泌]