Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis  

作　　者：Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand 

机构地区：[1]Department of Internal Medicine ,University Medical Center Regensburg,D-93042 Regensburg,Germany [2]Department of Psychiatry,University Medical Center Regensburg,D-93042 Regensburg,Germany

出　　处：《World Journal of Gastroenterology》2009年第44期5558-5562,共5页世界胃肠病学杂志（英文版）

摘　　要：AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP.AIM： To investigate a genetic polymorphism of the monocyte chemotactic protein-1 （MCP-1） gene in patients with spontaneous bacterial peritonitis （SBP）. METHODS： MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites. RESULTS： The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However, in the subgroup of patients with alcoholic cirrhosis （n = 80）, carriers of the G-allele were significantly less frequent in SBP- patients （38.1%） than in cirrhotic controls （67.8%, P = 0.021）. CONCLUSION： In patients with alcoholic liver cirrhosis, the -2518 MCP-1 genotype AA is a risk factor for the development of SBP.

关 键 词：Monocyte chemotactic protein-1 CHEMOKINES Spontaneous bacterial peritonitis POLYMORPHISM LIVERCIRRHOSIS 

分 类 号：R572.2[医药卫生—消化系统]