不同临床类型HBV感染者外周血T细胞亚群的差异  

Differences in peripheral T-cell subsets among different clinical types of hepatitis B patients

作　　者：刘俊英[1] 杨京[2] 贾红云[1] 

机构地区：[1]河南省周口市中心医院消化内科,河南省周口市466000 [2]贵阳医学院附属医院感染科,贵州省贵阳市550004

出　　处：《世界华人消化杂志》2009年第29期3038-3042,共5页World Chinese Journal of Digestology

摘　　要：目的:观察不同临床类型HBV感染者外周血T淋巴细胞亚群的差异.方法:收集2006-9/2009-03贵阳医学院附属医院门诊及住院部慢性HBV携带者30例、慢性乙型肝炎患者47例、重型乙型肝炎患者26例以及非乙型肝炎且无影响T细胞亚群疾患者34例(高血压15例,冠心病9例,非甾体药物相关性消化性溃疡10例)的外周血,用流式细胞技术检测T细胞亚群.结果:慢性HBV携带者组、慢性乙型肝炎患者组及重型乙型肝炎患者组外周血中CD3+、CD4+、CD8+T细胞计数及CD3+、CD4+T细胞百分数及CD4+/CD8+(计数与百分数比)均较正常对照组明显降低(P<0.05或0.01),CD8+T细胞百分数明显升高(P<0.05或0.01),以上改变有统计学意义,且不同组间对比也有不同程度的统计学差异(P<0.05或0.01).结论:不同临床类型的慢性HBV感染者均存在不同程度的细胞免疫功能低下及免疫调节紊乱,紊乱的程度与病情的进展有关.AIM： To observe the differences in T-lymphocyte subsets among different clinical types of chronic hepatitis B （CHB） patients. METHODS： Forty-seven CHB patients, 30 HBV carriers, 26 severe hepatitis patients, and 34 patients with other diseases that do not affect T-lymphocyte subsets （including 15 patients with hypertension, 9 patients with coronary heart disease, and 10 patients with non-steroidal antiinflammatory drug-related peptic ulcer） were included in the study. All the patients were treated at the Affiliated Hospital of Guiyang Medical College from September 2006 to March 2009. The peripheral T-lymphocyte subsets in these patient were determined by flow cytometry. RESULTS： The number of CD3＋, CD4＋ and CD8＋ T lymphocytes and the percentages of CD3＋ and CD4＋ T lymphocytes in peripheral blood as well as CD4＋/CD8＋ ratio in CHB patients, HBV carriers and serious hepatitis patients were significantly lower than those in control patients （all P 〈 0.05 or 0.01）. In contrast, the percentages of CD8＋ T lymphocytes in peripheral blood in CHB patients, HBV carriers and serious hepatitis patients were significantly higher than those in control patients （all P 〈 0.05 or 0.01）. Significant differences were also noted in the above parameters among CHB patients, HBV carriers and serious hepatitis patients. CONCLUSION： Varying degrees of decreased cellular immune function and immune dysregulation are noted in various clinical types of CHB patients.

关 键 词：HBV感染者 HBV携带者 慢性乙型肝炎 重型肝炎 T细胞亚群 

分 类 号：R512.62[医药卫生—内科学]