体质量指数变化与血压升高  

Impact of BMI Change on Blood Pressure

作　　者：李冬青[1] 陈磊[1] 吴寿岭[1] 赵洪涛[1] 程平[1] 杜鑫[1] 王庆蕊[1] 刘爱华[1] 马宇杰[1] 王剑利[1] 

机构地区：[1]华北煤炭医学院附属开滦医院心内科,河北唐山063000

出　　处：《中华高血压杂志》2009年第12期1085-1089,共5页Chinese Journal of Hypertension

摘　　要：目的观察体质量指数(BMI)变化对血压水平和原发性高血压(EH)发病率的影响。方法血压正常的健康者876例入选队列,于2002-06和2004-06随访测量入选者血压,于2006年对此队列人群进行第2次体检和问卷调查,对持续随访的813例入选者进行分析。观察BMI保持正常组(n=439)、BMI升高组(n=72)、BMI降低组(n=57)、持续高BMI组(n=245)4组研究对象BMI变化对血压水平和高血压发病率的影响。结果与2006年BMI保持正常组比较,BMI升高组的收缩压和舒张压均明显升高[收缩压:(120.6±17.8)比(114.9±14.9)mmHg,P=0.004;舒张压:(79.3±10.7)比(75.7±8.7)mmHg,P=0.002];持续高BMI组的收缩压和舒张压不明显升高[收缩压:(122.2±15.1)比(120.1±17.5)mmHg,P=0.371;舒张压:(80.1±9.7)比(77.6±10.3)mmHg,P=0.094]。与BMI保持正常组比较,BMI升高组高血压风险(RR)为2.067(1.145～3.372,P=0.016)、持续高BMI组1.813(1.203～2.743,P=0.004)。结论即使基线BMI正常的人,在2年内BMI增高到≥25 kg/m2,就会引起收缩压与舒张压明显增加,BMI增加的人发生高血压的危险与基线及随访期间BMI都持续增高的人相似,基线BMI≥25 kg/m2的人,低BMI对舒张压下降有效。Objective To study the impact of body mass index（BMI） change on blood pressure（BP）. Methods Eight hundred seventy-six healy, normotensive underwent physical and blood biochemistry examination and followed up for 2 years （2004--2006）. This cohort of population were classified according to the change of BMI in this period： sustained normal BMI （n=439）, increased BMI from〈25 to ≥25 kg/m^2 （n=72）, reduced BMI from ≥25 to 〈25 kg/m^2 （n=57）, and sustained high BMI≥25 kg/m^2 （n=245）. Results Compared with sustained normal BMI group, the subjects whose BMI increased from 〈25 to ≥25 kg/m^2 had sighnificant increases both inSBP [form （114.9±14.9） to （120.6±17.8） mmHg, P=0.004] and DBP[from （75.7±8.7） to （79.3± 10.7）mmHg, P = 0. 002], No changes in BP was found in other groups. Cox regression analysis showed subjects with increases in BMI had comparable RR becoming hypertension as that of sustained high BMI （2.067, 95% CI 1.145--3.372） vs （1.813, 95% CI 1.203--2.743, P〉0.05）. Conclusions Increases in BMI from a normal BMI level to ≥25 kg/m^2 confers comparable risk for developing hypertension as those with sustained high BMI. Reduction of BMI may associsted with lowering DBP. Prevention of increases in BMI is strongly advocated.

关 键 词：体质量指数 原发性高血压 发病率 血压水平 队列研究 

分 类 号：R544.1[医药卫生—心血管疾病]