A new mammalian circadian oscillator model including the cAMP module  

作　　者：王军威 周天寿 

机构地区：[1]School of Informatics,Guangdong University of Foreign Studies [2]School of Mathematics and Computational Science,Sun Yat-Sen University

出　　处：《Chinese Physics B》2009年第12期5552-5559,共8页中国物理B（英文版）

基　　金：Project supported by the State Key Program of National Natural Science Foundation of China (Grant No 60736028);the National Natural Science Foundation of China (Grant Nos 10871074 and 60704045);the Research Fund for the Doctoral Program of Higher Education of China (Grant No 20070558053)

摘　　要：In this paper, we develop a new mathematical model for the mammalian circadian clock, which incorporates both transcriptional/translational feedback loops （TTFLs） and a cAMP-mediated feedback loop. The model shows that TTFLs and cAMP signalling cooperatively drive the circadian rhythms. It reproduces typical experimental observations with qualitative similarities, e.g. circadian oscillations in constant darkness and entrainment to light dark cycles. In addition, it can explain the phenotypes of cAMP-mutant and Rev-erba^-/^- -mutant mice, and help us make an experimentally-testable prediction： oscillations may be rescued when arrhythmic mice with constitutively low concentrations of cAMP are crossed with Rev-erba^-/- mutant mice. The model enhances our understanding of the mammalian circadian clockwork from the viewpoint of the entire cell.In this paper, we develop a new mathematical model for the mammalian circadian clock, which incorporates both transcriptional/translational feedback loops （TTFLs） and a cAMP-mediated feedback loop. The model shows that TTFLs and cAMP signalling cooperatively drive the circadian rhythms. It reproduces typical experimental observations with qualitative similarities, e.g. circadian oscillations in constant darkness and entrainment to light dark cycles. In addition, it can explain the phenotypes of cAMP-mutant and Rev-erba^-/^- -mutant mice, and help us make an experimentally-testable prediction： oscillations may be rescued when arrhythmic mice with constitutively low concentrations of cAMP are crossed with Rev-erba^-/- mutant mice. The model enhances our understanding of the mammalian circadian clockwork from the viewpoint of the entire cell.

关 键 词：MAMMALS circadian clock CAMP transcriptional feedback loop 

分 类 号：Q41[生物学—生理学]