一种4-氮甾体激素化合物的合成  

Synthesis of a 4-azasteroid hormones compound

作　　者：臧红霞[1] 

机构地区：[1]邢台学院生物和化学系,河北邢台054001

出　　处：《现代化工》2009年第12期57-59,共3页Modern Chemical Industry

摘　　要：以孕甾双烯醇酮醋酸酯为起始原料,经次溴酸钠氧化、甲醇甲酯化得到3-羰基-4-雄甾烯-17-羧酸甲酯,再经Oppe-nauer氧化、双键的氧化切断、氨解环合、Δ5双键加氢、酯氨解反应得酰胺类中间产物,然后碘化和脱碘反应进行1,2位脱氢合成非那甾胺。Pregnadienolone acetate is converted to 3-oxo-4-androstene-17-carboxylic methyl ester by hypobromous acid oxidation and ethanol esterification, then to give amide intermediates by Oppenauer oxidation, cleavage of △4 double bond by oxidation, ring closure by ammonia, hydrogenation of △5 double bond and ester ammonolysis. At last Finasteride is prepared by dehydrogenation of 1,2-position in A-ring with iodination and iodine removal.

关 键 词：非那甾胺 N-叔丁基-3-羰基-4-氮杂-5-雄甾-17β-甲酰胺 合成 中间体 

分 类 号：TQ016[化学工程]