中草药代谢与细胞色素P450的关系研究进展  

Review on Interaction between Herb Metabolism and Cytochrome P450

作　　者：翁小刚[1] 朱晓新[1] 梁日欣[1] 杨庆[1] 李玉洁[1] 王怡薇[1] 刘晓霓[1] 韩晓[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2009年第12期104-108,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技支撑计划"十一五"项目子课题(2006BAI08B04-4);国家自然科学基金重大研究计划项目--中医药几个关键问题研究(90709017);国家中医药管理局中医药行业科研专项项目(2008070036);中国中医科学院自主选题(ZZ2006102)

摘　　要：目的:阐述中草药代谢与细胞色素P450酶(CYP450)的关系。方法:查阅近年来国内外相关文献100余篇,从CYP450概述、CYP450研究方法、代谢性相互作用以及中草药-药物相互作用与CYP450之间关系等方面进行文献归纳。结果:CYP450研究方法主要包括体外细胞、亚细胞水平研究及体内研究,CYP450酶活性改变是代谢性相互作用的主要原因,中草药复杂成分对CYP450酶活性影响较大。结论:CYP450在药物代谢中起重要作用,由中草药引起药物相互作用屡的原因大多缘于中草药影响了机体CYP450活性或机体CYP450蛋白表达,导致由CYP450参与代谢的其它药物在机体内代谢特征的改变,引发不良药物反应。Objective：To outlines the interaction between herbs metabolism and CYP450.Methods：Refer to more than 100 piece of literatures about CYP450 and sum up the article from conception of CYP450,study methods of CYP450,metabolism interaction and herbs metabolism.Results：study methods of CYP450 include methods in vitro and in vivo,and alteration in enzymic activity of CYP450 is reason of metabolism interaction.Conclusions：CYP450 plays an important role in drug metabolism;herbs have complicated ingredients and are reported to revoke some drug interaction often.The reason why drug interaction are caused by herbs is because these herbs affect activity or protein expression of CYP450 in organism and result in alteration of metabolism involved CYP450 of drugs thus to cause adverse drug reaction.

关 键 词：细胞色素P450酶 中草药代谢 药物相互作用 

分 类 号：R285.5[医药卫生—中药学] R969.1[医药卫生—中医学]