牙周局部缓释给药系统研究进展  

Advance in research on periodontal sustained-release local drug delivery systems

作　　者：刘庆晓[1,2] 杨美燕[1] 高春生[1,2] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850 [2]河南大学药学院,开封475004

出　　处：《中国新药杂志》2009年第23期2228-2232,共5页Chinese Journal of New Drugs

摘　　要：牙周病是局部炎症破坏性疾病,是人类最常见的口腔疾病之一。与全身给药相比,牙周局部缓释给药系统不仅使药物在牙周袋内达到高浓度,持续杀灭牙周致病菌,而且可以减少全身给药造成的不良反应和细菌耐药性。因此运用局部缓释给药系统治疗牙周病已成为国内外的研究热点,目前已有纤维剂、膜剂、微球、缓释凝胶、棒剂和口腔黏膜粘附片等牙周局部缓释给药系统在临床中使用或已有文献报道。文中主要围绕治疗牙周病的各种局部给药剂型的处方设计原理、关键辅料性质及其制剂优缺点等,详细综述牙周局部缓释给药系统的研究进展。Periodontal disease is a kind of local inflammatory and destructive diseases, and it is one of the most common human oral diseases. Compared with systemic administration, periodontal sustained-release local drug delivery systems can not only achieve high drug concentration and slow drug release in periodontal pocket, but also minimize side effects and bacterial resistance to drugs caused by systemic administration. Therefore, periodontal sustained -release local drug delivery systems have become the focus of the study on periodontal disease therapy at home and abroad. At present, the periodontal sustained-release local drug delivery systems include fiber, film, microspheres,gels, stylus and bucco-adhesive tablets. In this article, we reviewed the advance in research on periodontal sustained-release local drug delivery systems.

关 键 词：牙周病 局部给药 缓释凝胶 盐酸多西环素 

分 类 号：R944.9[医药卫生—药剂学]