BINSWANGER病颈动脉IMT与IGF-1相关性研究  

Relative Research on IGF-1 and IMT of Carotid Artery of Binswanger Disease

作　　者：田欢[1] 刘晓平[1] 红华[1] 

机构地区：[1]内蒙古自治区医院超声科,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2009年第11期1288-1290,共3页Inner Mongolia Medical Journal

摘　　要：目的:探讨Binswanger病颈动脉内膜-中层厚度(inti ma-media thickness,I MT)和血清胰岛素样生长因子-1(insulin 1ike growth factor-1,IGF-1)的相关性。方法:54例经临床确诊为Binswanger病(Binswanger’s disease BD)患者(经神经心理学检测分为3组:轻度痴呆22例、中度痴呆17例、重度痴呆15例)和30例门诊健康体检志愿者,用二维超声检测颈动脉内中膜厚度,同时测定静脉血胰岛素样生长因子-1(IGF-1)水平,并进行统计分析。结果:BD组血清IGF-I水平均明显低于健康对照组(P<0.05),轻度痴呆组和中度痴呆组差异有统计学意义(P<0.05),中度痴呆组和重度痴呆组比较有显著性差异(P<0.05)。血清IGF-I水平和颈动脉内膜-中层厚度呈中度负相关(r=-0.453),BD患者的颈动脉内膜-中层厚度均明显高于对照组(P<0.05),轻度痴呆组和中、重度痴呆组之间差异有统计学意义(P<0.05),中、重度痴呆组之间差异有统计学意义(P<0.05)。结论:血清IGF-1水平和颈动脉超声相结合,有助于BD痴呆程度的判断,为临床早期治疗BD提供可靠的依据。Objective：To explore the relation between the level of serum insulin 1ike growth factor-1（IGF-1）in patients with Binswanger＇s disease and their intima-media thickness（IMT）of carotid artery.Methods： Fifty-four patients suffering from Binswanger＇s disease were divided into 3 groups by neuropsychological test（1group mild dementia,2 group moderate dementia,3 group severe dementia） and thirty healthy volunteers constituted normal group underwent carotid artery ultrasonography.the serum IGF-1 level were measured and the intima-media thickness（IMT）of carotid artery were measured by ultrasonography.Results： The serum IGF-1 level in all BD groups were obviously lower than control（P〈0.05）.2 group and 3 group obviously differed from 1 group（P〈0.05）.The intima-media thickness（IMT）of carotid artery in BD group was significantly thicker than control group（P〈0.05）.the serum level of IGF-1 had negative relation with IMT（P〈0.05）.Conclusions： The serum IGF-1 level and carotid artery ultrasonography is contribute to differential dignosis the degree of dementia,then supply reliable information to early therapy of BD.

关 键 词：BINS WANGER病 胰岛素样生长因子 颈动脉内膜-中层厚度 

分 类 号：R540.48[医药卫生—心血管疾病] R731.1[医药卫生—内科学]