褐藻酸钙-壳聚糖胃漂浮微丸漂浮性能研究  

Study on the floating characteristics of the calcium alginate-chi-tosan intragastric floating beads

作　　者：蒋慧明[1,2] 张良珂[1,2] 张华[1,2] 张佩瑜[1,2] 刘文利[1] 

机构地区：[1]重庆医科大学药学院重庆市生物化学与分子药理学重点实验室,重庆400016 [2]重庆医科大学高校药物工程研究中心,重庆400016

出　　处：《中国海洋药物》2009年第6期14-18,共5页Chinese Journal of Marine Drugs

基　　金：重庆市科委自然科学基金资助项目(CSTC;2008BB5397);重庆医科大学校办课题资助(XBYB2007098;NSFYY200728)

摘　　要：目的制备褐藻酸钙-壳聚糖胃漂浮型微丸,并考察各因素对微丸漂浮性能的影响。方法将添加制泡剂的褐藻酸钠溶液缓慢滴入添加醋酸的壳聚糖-氯化钙溶液中,干燥后得到褐藻酸钙-壳聚糖胃漂浮型微丸,考察制泡剂和醋酸加入量,褐藻酸钠溶液浓度,壳聚糖浓度及氯化钙浓度对微丸漂浮性能的影响。结果制泡剂和醋酸加入量是漂浮性能主要影响因素,同时褐藻酸钠溶液浓度,壳聚糖浓度及氯化钙浓度也有一定影响。结论制泡剂和醋酸加入量是漂浮性能主要影响因素,同时褐藻酸钠溶液浓度,壳聚糖浓度及氯化钙浓度也有一定影响。结论成功制备具有良好漂浮性能的褐藻酸钙-壳聚糖胃漂浮型微丸,为开发新型多单元胃漂浮给药系统提供试验依据。Objective To prepare calcium alginate-chitosan intragastric floating beads and investigate the influences of various factors on the floating characteristics of beads. Methods Sodium alginate solution added with frother was slowly dripped into chitosan-calcium chloride solution added with acetic acid, calcium alginate-chitosan intragastric floating beads were obtained after drying. The effects of frother, addition amount of acetic acid,the concentration of alginate solution,chitosan and calcium chloride solution on the floating characteristics of beads were investigated. Results Frother and addition amount of acetic acid were the main influence factors on the floating characteristics, and the concentrations of alginate solution, chitosan and calcium chloride solution also had some influences. Conclusion The calcium alginate-chitosan intragastric floating beads with favorable floatability could be achieved through adjusting the formula, it laid a foundation for the furether development of the preparations in intragastric floating preparations.

关 键 词：褐藻酸钙 壳聚糖 胃漂浮 微丸 

分 类 号：R931.711[医药卫生—生药学] R965[医药卫生—药学]