维生素D受体基因多态性与成人迟发自身免疫型糖尿病的相关性研究  

The association of Vitamin D Receptor gene polymorphism with latent autoimmune diabetes in adults

作　　者：丁洪光[1,2] 刘鹏鹰[2] 刘君英[2] 李瑛[2] 叶辉[2] 邬磊[2] 黄耀辉[2] 

机构地区：[1]广州医学院,广东广州510182 [2]深圳市第二人民医院,广东深圳518035

出　　处：《深圳中西医结合杂志》2009年第6期336-338,355,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：深圳市卫生局科技项目(A2001626)

摘　　要：目的:探讨维生素D受体(VDR)基因BsmⅠ酶切位点多态性与深圳市成人迟发性自身免疫性糖尿病(LADA)的关系。方法:对25例LADA、32例2型糖尿病(T2DM)患者和30例正常人(NC)采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术分析VDR-BsmⅠ位点基因型。结果:T_2DM患者VDR基因B等位基因频率明显高于正常对照组(20.3%vS.6.7%,P<0.05),基因型Bb明显高于正常对照组(40.6%vS.13.3%,P<0.05),基因型bb明显低于正常对照组(59.4%vS.86.7%,P<0.05);LADA患者Bb基因型频率以及B等位基因频率与对照组比较差异无统计学意义(P>0.05)。结论:VDR基因BsmⅠ位点多态性与LADA易感性可能无关,但与T_2DM的易感性密切相关。Objective To investigate the association of vitamin D receptor（VDR） gene polymorphism with latent autoimmune diabetes in adults. Methods The VDR-Bsm I phenotype was detemined by PCR-RFLP method in 25 LADA patients,32 type 2 diabetes mellitus patients and 30 healthy control subjects. Results A highly significant increase in the frequency of the B allele was seen in T2DM patients compared with controls（20,3% vs.6.7%, P〈0.05）,This reflected an increase in the Bb genotype in patients（40.6% vs. 13.3%, P〈0.05 ）and a significant decrease in the bb genotype（59.4% vs.86.7% , P〈0.05）.The Bb or bb frequency was not significantly higher in patients with LADA than in the control group（P〉0.05）, and so was the B allele. Conclusions The study shows that the vitamin D receptor Bsm I polymorphism may be not related to LADA,but may be tightly related to T2DM.

关 键 词：维生素D受体(VDR) 基因多态性 成人迟发自身免疫性糖尿病(LADA) 

分 类 号：R587.1[医药卫生—内分泌]