胰岛B细胞特异性锌转运蛋白与1型糖尿病  

The islet beta-cell-specific zinc transporter isoform 8 in type 1 diabetes mellitus

作　　者：邢春燕[1] 刘煜[2] 

机构地区：[1]南京医科大学第一附属医院内分泌科,江苏南京210029 [2]吉林大学第二医院内分泌科,吉林长春130041

出　　处：《国际内科学杂志》2009年第12期693-696,共4页International Journal of Internal Medicine

摘　　要：1型糖尿病(T1DM)是胰岛呈进行性破坏的自身免疫性疾病,以表达于胰岛B细胞的分子靶点作为抗原参与自身免疫反应为特征。其中阳离子外流锌转运蛋白8(ZnT8,SLC30A8)是人类T1DM的主要自身抗原之一,T1DM患者中SLC30A8基因位点上氨基酸325的多态性决定了其自身抗体多肽的特异性。ZnT8自身抗体可以在新发T1DM和糖尿病前期患者血清中检测出,在T1DM患者血清中其他自身抗体(谷氨酸脱羧酶抗体、抗酪氨酸磷酸酶抗体、抗胰岛素抗体和抗胰岛细胞抗体)阴性时ZnT8抗体仍有26%的阳性率。对自身抗体ZnT8的检测有助于在人群中筛查糖尿病前期患者,因此检测ZnT8抗体对评估T1DM的发生发展是必要的,ZnT8(SLC30A8)是T1DM的一个重要并独立的预测因子。Type 1 diabetes mellitus（T1DM） is an autoimmune disease results as progressive loss of pancreatic islet through autoimmunity targeted at molecules expressed on the pancreatic beta cells. The cation effiux transporter ZnT8 （ SLC30A8 ） is a major autoantigen in human T1DM, and the polymorphism at aa 325 of SLC30A8 has been implicated in T1DM by determining the autoantibody epitope specificity and in type 2 diabetes through being associated with altered beta-cell mass and impaired secretion. ZnT8 autoantibody can be screened in new-onset T1DM and prediabetic subjects. ZnT8 autoantibody was positive in 26% of T1DM subjects whose glutamie acid decarboxylase antibodies, tyrosine phosphatase IA2 （IA2A）, insulin antibody （IAA） , and islet cell antibody（ICA） were negative. Detection of ZnT8 is essential in evaluating the development of T1DM and helpful for screening prediabetes in the general population.

关 键 词：锌转运蛋白8 1型糖尿病 锌离子 多态性 自身抗体 

分 类 号：R587.1[医药卫生—内分泌]