转录因子在心肌肥大中的调控作用  

Regulatory roles of cardiac transcription factors in cardiac hypertrophy

作　　者：白宝宝[1] 孙智慧[1] 陶谦民[1] 

机构地区：[1]浙江大学医学院附属第一医院心血管内科,浙江杭州310003

出　　处：《国际内科学杂志》2009年第12期705-709,共5页International Journal of Internal Medicine

摘　　要：虽然近年来对心力衰竭的治疗有了很大的进步,但其病死率、致残率仍然很高。心肌重构是心力衰竭发展的一个重要病理机制,目前认为抑制心肌重构是预防和治疗心力衰竭的重要手段,而心肌细胞肥大是心力衰竭发展过程中心肌重构的一个主要特征之一。大量研究表明心肌细胞转录因子在心肌细胞肥大过程中起重要调控作用,一些心肌细胞转录因子在受到肥大刺激信号作用后能够被激活并且在心肌肥大过程中起重要作用。该文对几种转录因子在心肌细胞肥大过程中的最新研究状况作一简单介绍。Although therapy of heart failure made great progress in recent years, it still has high mortality and morbidity. Myocardial remodeling is the main mechanism in the progress of heart failure. Myocardial hypertrophy is one of key features of myocardial remodeling. Myocardial transcription factor acting as regulator in myocardial hypertrophy have been extensively investigated, some transcription factors have been activated by hypertrophy stimulators and then play a essential role in myocardial hypertrophy. In this review, the regulation of cardiac hypertrophy by cardiac transcription factors is summarized.

关 键 词：心肌肥大 转录因子 调控 信号转导 

分 类 号：R541.6[医药卫生—心血管疾病]