长白山产紫草化学成分研究  

Chemical constituents of Zicao(Radix Arnebiae) from the Changbai Mountains

作　　者：刘洁宇[1,2] 徐新刚[1] 刘松艳[2] 王聪[1] 张宏桂[1] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]吉林大学化学学院

出　　处：《北京中医药大学学报》2009年第11期773-775,共3页Journal of Beijing University of Traditional Chinese Medicine

摘　　要：目的考察长白山产紫草的化学成分。方法石油醚加热回流提取,硅胶柱层析和制备硅胶薄层分离,重结晶得到单体化合物,利用理化性质及波谱学方法鉴定结构。结果分离鉴定了5个化合物,分别是去氧紫草素、β,β-二甲基丙烯酰紫草素、乙酰紫草素、2,3-二甲基戊烯酰紫草素和紫草素。结论去氧紫草素、β,β-二甲基丙烯酰紫草素、乙酰紫草素、2,3-二甲基戊烯酰紫草素和紫草素均为在长白山产紫草植物中首次发现。所得化学成分均为长白山产紫草与道地紫草所共有。Objective To investigate the chemical constituents of Zicao（Radix Arnebiae） produced from Changbai Mountain.Methods Multi-chromatographic methods including reflux of petroleum ether,silica gel column chromatograph,preparative TLC and recrystallization were used to isolate the extracts from Zicao to get the monomeric compounds.The chemical structures of the extracts were identified based on the physicochemical characters and spectroscopic data.Results There were 5 chemical compounds extracted from Zicao,including deoxyshikonin,β,β＇-dimethyl-acryl-shikonin,acetylshikonin,teracryl-shikonin and shikonin.Conclusion Deoxyshikonin,β,β＇-dimethyl-acryl-shikonin,acetylshikonin, teracryl-shikonin and shikonin are found in Zicao produced from Changbai Mountain for the first time. The chemical constituents identified in Zicao produced from Changbai Mountain are the same as those in authentic Zicao.

关 键 词：长白山 紫草 化学成分 

分 类 号：R284.1[医药卫生—中药学]